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    CTSK cathepsin K [ Bos taurus (domestic cattle) ]

    Gene ID: 513038, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CTSKprovided by VGNC
    Official Full Name
    cathepsin Kprovided by VGNC
    Primary source
    VGNC:VGNC:27817
    See related
    BGD:BT21697; Ensembl:ENSBTAG00000021035
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CTSK in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (19953196..19966059)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene cAMP-regulated phosphoprotein 19 Neighboring gene cathepsin S

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Inverse relationship between autophagy and CTSK is related to bovine embryo quality. Balboula AZ, et al. Reproduction, 2020 Jun. PMID 32224503
    2. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    3. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inverse relationship between autophagy and CTSK is related to bovine embryo quality.
      Title: Inverse relationship between autophagy and CTSK is related to bovine embryo quality.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC134021

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin K
    Names
    cathepsin K preproprotein
    NP_001029607.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034435.1 → NP_001029607.1  cathepsin K precursor

      See identical proteins and their annotated locations for NP_001029607.1

      Status: PROVISIONAL

      Source sequence(s)
      BT021052
      UniProtKB/Swiss-Prot
      Q5E968
      UniProtKB/TrEMBL
      A0AAF6Z8G6
      Related
      ENSBTAP00000028016.7, ENSBTAT00000028016.7
      Conserved Domains (2) summary
      smart00848
      Location:31 → 90
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:120 → 332
      Peptidase_C1; Papain family cysteine protease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      19953196..19966059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E968.2 GenPept UniProtKB/Swiss-Prot:Q5E968

    Gene LinkOut

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