ASH1L ASH1 like histone lysine methyltransferase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ASH1Lprovided by VGNC
Official Full Name: ASH1 like histone lysine methyltransferaseprovided by VGNC
Primary source: VGNC:VGNC:50606
See related: BGD:BT28078; Ensembl:ENSBTAG00000003954
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (15090422..15298435)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-35091 (e-PCR)
- UniSTS:37399

BZ948493 (e-PCR)
- UniSTS:475045

RH69490 (e-PCR)
- UniSTS:18661

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables histone H3K4 methyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histone-lysine N-methyltransferase ASH1L

NP_001179672.1

EC 2.1.1.354

XP_010801223.1

EC 2.1.1.354

XP_010801225.1

EC 2.1.1.354

XP_010801226.1

EC 2.1.1.354

XP_015317788.1

EC 2.1.1.354

XP_024845407.1

EC 2.1.1.354

XP_024845408.1

EC 2.1.1.354

XP_024845409.1

EC 2.1.1.354

XP_059740790.1

EC 2.1.1.354

XP_059740791.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192743.1 → NP_001179672.1 histone-lysine N-methyltransferase ASH1L

See identical proteins and their annotated locations for NP_001179672.1

Status: PROVISIONAL

Source sequence(s)

NKLS02000003

Conserved Domains (5) summary

cd05525
Location:2439 → 2544

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2088 → 2139

AWS; associated with SET domains

smart00317
Location:2142 → 2262

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2661 → 2795

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2582 → 2624

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

15090422..15298435

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_010802923.4 → XP_010801225.1 histone-lysine N-methyltransferase ASH1L isoform X1

See identical proteins and their annotated locations for XP_010801225.1

Conserved Domains (5) summary

cd05525
Location:2439 → 2544

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2088 → 2139

AWS; associated with SET domains

smart00317
Location:2142 → 2262

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2661 → 2795

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2582 → 2624

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_024989639.2 → XP_024845407.1 histone-lysine N-methyltransferase ASH1L isoform X1

Conserved Domains (5) summary

cd05525
Location:2439 → 2544

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2088 → 2139

AWS; associated with SET domains

smart00317
Location:2142 → 2262

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2661 → 2795

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2582 → 2624

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_015462302.3 → XP_015317788.1 histone-lysine N-methyltransferase ASH1L isoform X1

Conserved Domains (5) summary

cd05525
Location:2439 → 2544

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2088 → 2139

AWS; associated with SET domains

smart00317
Location:2142 → 2262

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2661 → 2795

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2582 → 2624

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_010802921.4 → XP_010801223.1 histone-lysine N-methyltransferase ASH1L isoform X1

See identical proteins and their annotated locations for XP_010801223.1

Conserved Domains (5) summary

cd05525
Location:2439 → 2544

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2088 → 2139

AWS; associated with SET domains

smart00317
Location:2142 → 2262

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2661 → 2795

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2582 → 2624

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_010802924.4 → XP_010801226.1 histone-lysine N-methyltransferase ASH1L isoform X2

UniProtKB/TrEMBL

E1BGA4

Related

ENSBTAP00000005172.6, ENSBTAT00000005172.7

Conserved Domains (5) summary

cd05525
Location:2379 → 2484

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2028 → 2079

AWS; associated with SET domains

smart00317
Location:2082 → 2202

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2601 → 2735

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2522 → 2564

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_059884807.1 → XP_059740790.1 histone-lysine N-methyltransferase ASH1L isoform X3
XM_024989640.2 → XP_024845408.1 histone-lysine N-methyltransferase ASH1L isoform X4

Conserved Domains (5) summary

cd05525
Location:2255 → 2360

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:1904 → 1955

AWS; associated with SET domains

smart00317
Location:1958 → 2078

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:2477 → 2611

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2398 → 2440

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L
XM_059884808.1 → XP_059740791.1 histone-lysine N-methyltransferase ASH1L isoform X4
XM_024989641.2 → XP_024845409.1 histone-lysine N-methyltransferase ASH1L isoform X5

Conserved Domains (5) summary

cd05525
Location:719 → 824

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:368 → 419

AWS; associated with SET domains

smart00317
Location:422 → 542

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

cd04717
Location:941 → 1075

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:862 → 904

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L