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    Sem1 Suppressor of exocyst mutations 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sem1provided by FlyBase
    Official Full Name
    Suppressor of exocyst mutations 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0266666
    Locus tag
    Dmel_CG13779
    See related
    AllianceGenome:FB:FBgn0266666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH34416; CG13779; dmdss1; Dmel\CG13779; dss1; DSS1; sem1; Sem1p
    Summary
    Predicted to be involved in double-strand break repair via homologous recombination and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. Is expressed in embryonic/larval midgut and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sem1 in Genome Data Viewer
    Location:
    27D7-27D7; 2-24 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7063986..7064467)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7063986..7064467)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene caper Neighboring gene milton Neighboring gene Menin 1 Neighboring gene Male specific transcript 27D Neighboring gene Nuf2 Neighboring gene UDP-glycosyltransferase family 307 member A1 Neighboring gene PDGF- and VEGF-related factor 2 Neighboring gene long non-coding RNA:CR44611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens. Mota MBS, et al. Parasit Vectors, 2019 Nov 11. PMID 31711518, Free PMC Article
    2. Functional analysis of Drosophila melanogaster BRCA2 in DNA repair. Brough R, et al. DNA Repair (Amst), 2008 Jan 1. PMID 17822964
    3. Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Cerrato A, et al. Dev Biol, 2006 Oct 1. PMID 16930585, Free PMC Article
    4. A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings. Carvajal-Gonzalez JM, et al. G3 (Bethesda), 2016 Dec 7. PMID 27729438, Free PMC Article
    5. Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A. Mahesh G, et al. Sci Rep, 2020 Oct 21. PMID 33087840, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of exocyst mutations 1
    Names
    CG13779-PA
    Sem1 ortholog
    Sem1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7063986..7064467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144298.4 → NP_652555.1  suppressor of exocyst mutations 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VM46
      Related
      FBpp0079031
      Conserved Domains (1) summary
      pfam05160
      Location:43 → 73
      DSS1_SEM1; DSS1/SEM1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VM46.1 Q9VM46

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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