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    S1PR1 sphingosine-1-phosphate receptor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281135, updated on 1-Jan-2025

    Summary

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    Official Symbol
    S1PR1provided by VGNC
    Official Full Name
    sphingosine-1-phosphate receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:34252
    See related
    BGD:BT10772; Ensembl:ENSBTAG00000005990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    EDG1; S1P1
    Orthologs
    human mouse all
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    Genomic context

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    See S1PR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (42034669..42039324, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene olfactomedin 3 Neighboring gene uncharacterized LOC132344992 Neighboring gene ATP synthase subunit e, mitochondrial-like Neighboring gene craniofacial development protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Novel SNP in 5' flanking region of EDG1 associated with marbling in Japanese Black beef cattle. Yamada T, et al. Anim Sci J, 2009 Aug. PMID 20163611
    2. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Igarashi J, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12963813, Free PMC Article
    3. Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation. Langlois S, et al. Blood, 2004 Apr 15. PMID 15070679
    4. Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing. Lee H, et al. Am J Physiol Cell Physiol, 2000 Mar. PMID 10712250
    5. Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle. Sukegawa S, et al. Anim Sci J, 2014 Mar. PMID 24033432

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings suggest the presence of inter-allelic interactions among genes affecting the development of beef marbling.
      Title: Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle.
    2. Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
      Title: Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
    3. we detected 2 novel SNPs, referred to as g.1475435G>A and g.1471620G>T, in the 5' flanking region of the EDG1 between low-marbled and high-marbled steer groups
      Title: Novel SNP in 5' flanking region of EDG1 associated with marbling in Japanese Black beef cattle.
    4. EDG1 SNPs, although they may not be regarded as a causal mutation, may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle.
      Title: Association of single nucleotide polymorphisms in the endothelial differentiation sphingolipid G-protein-coupled receptor 1 gene with marbling in Japanese Black beef cattle.
    5. induction by vascular endothelial growth factors in endothelial cells
      Title: VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137514

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sphingosine-1-phosphate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sphingosine 1-phosphate receptor 1
    Names
    S1P receptor 1
    S1P receptor Edg-1
    endothelial differentiation G-protein coupled receptor 1
    endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
    sphingosine 1-phosphate receptor Edg-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013585.4 → NP_001013603.2  sphingosine 1-phosphate receptor 1

      See identical proteins and their annotated locations for NP_001013603.2

      Status: PROVISIONAL

      Source sequence(s)
      BC114045
      UniProtKB/Swiss-Prot
      Q5E9P3
      Related
      ENSBTAP00000082935.1, ENSBTAT00000096753.1
      Conserved Domains (1) summary
      cd15346
      Location:46 → 322
      7tmA_S1PR1_Edg1; sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      42034669..42039324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5E9P3.1 GenPept UniProtKB/Swiss-Prot:Q5E9P3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.