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    l(1)G0196 lethal (1) G0196 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(1)G0196provided by FlyBase
    Official Full Name
    lethal (1) G0196provided by FlyBase
    Primary source
    FLYBASE:FBgn0027279
    Locus tag
    Dmel_CG14616
    See related
    AllianceGenome:FB:FBgn0027279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14616; CG32502; Dmel\CG14616
    Summary
    Predicted to enable ATP binding activity and inositol phosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval dorsal vessel; embryonic/larval midgut; and nephrocyte. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 100. Orthologous to human PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1) and PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(1)G0196 in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22487180..22508129)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21889016..21909965)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43493 Neighboring gene Centriolar coiled coil protein 110kDa Neighboring gene long non-coding RNA:CR43962 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S6 kinase II Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development. Morriss GR, et al. Genetics, 2013 Nov. PMID 24026097, Free PMC Article
    2. CP110 exhibits novel regulatory activities during centriole assembly in Drosophila. Franz A, et al. J Cell Biol, 2013 Dec 9. PMID 24297749, Free PMC Article
    3. MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Larschan E, et al. Mol Cell, 2007 Oct 12. PMID 17936709
    4. Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage. Mancheno-Ferris A, et al. iScience, 2024 Jan 19. PMID 38174321, Free PMC Article
    5. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22494434-22494999 mobile_element_type = transposon:INE-1{}3083
    • Loc: 22497148-22497183 mobile_element_type = transposon:INE-1{}3084
    • Loc: 22506428-22506956 mobile_element_type = transposon:INE-1{}3086

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lethal (1) G0196
    Names
    CG14616-PG
    CG14616-PH
    CG14616-PI
    CG14616-PJ
    CG14616-PK
    CG14616-PL
    CG14616-PM
    CG14616-PN
    CG14616-PO
    CG14616-PP
    l(1)G0196-PG
    l(1)G0196-PH
    l(1)G0196-PI
    l(1)G0196-PJ
    l(1)G0196-PK
    l(1)G0196-PL
    l(1)G0196-PM
    l(1)G0196-PN
    l(1)G0196-PO
    l(1)G0196-PP
    NP_001097041.2
    NP_001285532.1
    NP_001285533.1
    NP_001285534.1
    NP_001285535.1
    NP_001285536.1
    NP_788950.2
    NP_788951.2
    NP_788952.2
    NP_788953.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22487180..22508129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298606.1 → NP_001285535.1  lethal (1) G0196, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCY0
      Conserved Domains (1) summary
      pfam00328
      Location:406 → 930
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    2. NM_176777.2 → NP_788950.2  lethal (1) G0196, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788950.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2VEZ0, A8JUU5, Q6AWF3, Q8IQ22, Q8IQ23, Q8IQ24, Q9VR59
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    3. NM_001298607.1 → NP_001285536.1  lethal (1) G0196, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEN2
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    4. NM_001103571.2 → NP_001097041.2  lethal (1) G0196, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097041.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR59
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    5. NM_176780.2 → NP_788953.2  lethal (1) G0196, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788953.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR59
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    6. NM_176778.2 → NP_788951.2  lethal (1) G0196, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788951.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR59
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    7. NM_001298605.1 → NP_001285534.1  lethal (1) G0196, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JGE9
      Conserved Domains (1) summary
      pfam00328
      Location:402 → 926
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    8. NM_176779.3 → NP_788952.2  lethal (1) G0196, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788952.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VR59
      Conserved Domains (1) summary
      pfam00328
      Location:513 → 1037
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    9. NM_001298604.1 → NP_001285533.1  lethal (1) G0196, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JG41
      Conserved Domains (1) summary
      pfam00328
      Location:513 → 1034
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    10. NM_001298603.1 → NP_001285532.1  lethal (1) G0196, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JLN4
      Conserved Domains (1) summary
      pfam00328
      Location:513 → 1033
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR59.2 Q9VR59
    X2JCY0 X2JCY0
    X2JEN2 X2JEN2
    X2JG41 X2JG41
    X2JGE9 X2JGE9
    X2JLN4 X2JLN4

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