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    NBN nibrin [ Bos taurus (domestic cattle) ]

    Gene ID: 522943, updated on 29-Jan-2025

    Summary

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    Official Symbol
    NBNprovided by VGNC
    Official Full Name
    nibrinprovided by VGNC
    Primary source
    VGNC:VGNC:31895
    See related
    Ensembl:ENSBTAG00000013225
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NBN in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (73748773..73804383)

    Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene calbindin 1 Neighboring gene 2,4-dienoyl-CoA reductase 1 Neighboring gene oxidative stress induced growth inhibitor family member 2 Neighboring gene uncharacterized LOC101906456

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nibrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075837.2 → NP_001069305.2  nibrin

      Status: VALIDATED

      Source sequence(s)
      DV911905, EH145240, EH161526, EV787732
      UniProtKB/TrEMBL
      A0AAA9S1V8
      Related
      ENSBTAP00070025866.1, ENSBTAT00070043142.1
      Conserved Domains (4) summary
      cd00027
      Location:113 → 181
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      cd00060
      Location:1 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08599
      Location:683 → 745
      Nbs1_C; DNA damage repair protein Nbs1
      pfam16508
      Location:215 → 324
      NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      73748773..73804383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059893256.1 → XP_059749239.1  nibrin isoform X1

      UniProtKB/TrEMBL
      A0AAA9S1V8
      Related
      ENSBTAP00070025849.1, ENSBTAT00070043125.1

    2. XM_010812215.4 → XP_010810517.1  nibrin isoform X1

      See identical proteins and their annotated locations for XP_010810517.1

      UniProtKB/TrEMBL
      A0AAA9S1V8
      Conserved Domains (3) summary
      cd00027
      Location:32 → 100
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam08599
      Location:602 → 664
      Nbs1_C; DNA damage repair protein Nbs1
      pfam16508
      Location:134 → 243
      NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein
    Nucleotide Protein Strain
    Heading Accession and Version

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