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    NTN4 netrin 4 [ Bos taurus (domestic cattle) ]

    Gene ID: 537455, updated on 1-Jan-2025

    Summary

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    Official Symbol
    NTN4provided by VGNC
    Official Full Name
    netrin 4provided by VGNC
    Primary source
    VGNC:VGNC:32306
    See related
    Ensembl:ENSBTAG00000003183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See NTN4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (60031675..60161782, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132342120 Neighboring gene thymocyte expressed, positive selection associated 1 Neighboring gene uncharacterized LOC112446712 Neighboring gene U6 spliceosomal RNA Neighboring gene small nuclear ribonucleoprotein polypeptide F Neighboring gene coiled-coil domain containing 38 Neighboring gene amidohydrolase domain containing 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC160042

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in basement membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of laminin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    netrin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102203.1 → NP_001095673.1  netrin-4 precursor

      See identical proteins and their annotated locations for NP_001095673.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151286
      UniProtKB/TrEMBL
      A0AAA9TAW7, A7MB18, F1N0C1
      Conserved Domains (4) summary
      cd00055
      Location:261 → 320
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03578
      Location:515 → 625
      NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
      pfam00053
      Location:395 → 449
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:43 → 260
      Laminin_N; Laminin N-terminal (Domain VI)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      60031675..60161782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005206644.5 → XP_005206701.1  netrin-4 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TAW7
      Related
      ENSBTAP00000093797.1, ENSBTAT00000101351.1
      Conserved Domains (4) summary
      cd00055
      Location:261 → 320
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03578
      Location:516 → 626
      NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
      pfam00053
      Location:395 → 449
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:43 → 260
      Laminin_N; Laminin N-terminal (Domain VI)

    2. XM_010805194.4 → XP_010803496.1  netrin-4 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TAW7, A0AAF6DLX2
      Related
      ENSBTAP00000004136.6, ENSBTAT00000004136.7
      Conserved Domains (4) summary
      cd00055
      Location:261 → 320
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03578
      Location:520 → 630
      NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
      pfam00053
      Location:395 → 449
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:43 → 260
      Laminin_N; Laminin N-terminal (Domain VI)

    3. XM_024991956.1 → XP_024847724.1  netrin-4 isoform X1

      UniProtKB/TrEMBL
      A0AAA9SG89
      Related
      ENSBTAP00000081498.1, ENSBTAT00000126175.1
      Conserved Domains (5) summary
      smart00180
      Location:358 → 409
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:224 → 283
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03578
      Location:482 → 592
      NTR_netrin-4_like; NTR domain, Netrin-4-like subfamily; composed of the C-terminal NTR domains of netrin-4 (beta netrin) and similar proteins. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural ...
      pfam00053
      Location:295 → 355
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:6 → 223
      Laminin_N; Laminin N-terminal (Domain VI)
    Nucleotide Protein Strain
    Heading Accession and Version

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