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    sqa spaghetti-squash activator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqaprovided by FlyBase
    Official Full Name
    spaghetti-squash activatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259678
    Locus tag
    Dmel_CG42347
    See related
    AllianceGenome:FB:FBgn0259678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1776; CG30004; CG42347; Dmel\CG42347; FBgn0259678; Sqa
    Old locus tag
    Dmel_CG1776; Dmel_CG30004
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including compartment boundary maintenance; eye-antennal disc morphogenesis; and positive regulation of TOR signaling. Predicted to be active in cytoplasm. Is expressed in larval muscle system and larval somatic muscle cell. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to several human genes including MYLK3 (myosin light chain kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sqa in Genome Data Viewer
    Location:
    46B1-46B2; 2-61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9716348..9748121, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5603853..5635626, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44292 Neighboring gene uncharacterized protein Neighboring gene dacapo Neighboring gene Chemosensory protein A 46a Neighboring gene transient receptor potential-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. Champagne MB, et al. J Mol Biol, 2000 Jul 21. PMID 10891286
    2. Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Neubueser D, et al. Mol Biol Cell, 2010 Aug 15. PMID 20573980, Free PMC Article
    3. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Findlay GM, et al. Biochem J, 2007 Apr 1. PMID 17253963, Free PMC Article
    4. Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy. Tang HW, et al. EMBO J, 2011 Feb 16. PMID 21169990, Free PMC Article
    5. Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Xu J, et al. Dev Cell, 2018 Aug 6. PMID 30032991, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin light chain kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compartment boundary maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye-antennal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelial fold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    spaghetti-squash activator
    Names
    CG42347-PB
    CG42347-PC
    CG42347-PD
    MLCK-like
    sqa-PB
    sqa-PC
    sqa-PD
    NP_001260832.1
    NP_610514.1
    NP_724821.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9716348..9748121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273903.2 → NP_001260832.1  spaghetti-squash activator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Y7
      Conserved Domains (2) summary
      smart00220
      Location:34 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14103
      Location:40 → 289
      STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

    2. NM_165693.4 → NP_724821.2  spaghetti-squash activator, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724821.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Y7
      Conserved Domains (2) summary
      smart00220
      Location:34 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14103
      Location:40 → 289
      STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase

    3. NM_136670.3 → NP_610514.1  spaghetti-squash activator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610514.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SK9
      Related
      FBpp0289206
      Conserved Domains (2) summary
      smart00220
      Location:34 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14103
      Location:40 → 289
      STKc_MLCK; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7Y7 A1Z7Y7
    Q95SK9 Q95SK9

    Gene LinkOut

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