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    LARS1 leucyl-tRNA synthetase 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 509429, updated on 29-Jan-2025

    Summary

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    Official Symbol
    LARS1provided by VGNC
    Official Full Name
    leucyl-tRNA synthetase 1provided by VGNC
    Primary source
    VGNC:VGNC:30795
    See related
    Ensembl:ENSBTAG00000006765
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    LARS
    Orthologs
    human mouse all
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    Genomic context

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    See LARS1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (57327430..57397990, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene SH3 domain containing ring finger 2 Neighboring gene uncharacterized LOC112447446 Neighboring gene PLAC8 like 1 Neighboring gene RNA binding motif protein 27 Neighboring gene POU class 4 homeobox 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Leucyl-tRNA synthetase regulates lactation and cell proliferation via mTOR signaling in dairy cow mammary epithelial cells. Wang L, et al. Int J Mol Sci, 2014 Apr 9. PMID 24722568, Free PMC Article
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC143255

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables leucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in leucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine--tRNA ligase, cytoplasmic
    NP_001095962.1
    XP_005209595.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102492.1 → NP_001095962.1  leucine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_001095962.1

      Status: PROVISIONAL

      Source sequence(s)
      BC148056
      UniProtKB/TrEMBL
      A0A3Q1N108, A6QLR2, F1MEW2
      Related
      ENSBTAP00070045887.1, ENSBTAT00070075230.1
      Conserved Domains (5) summary
      cd07959
      Location:755 → 874
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:525 → 757
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:5 → 1062
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:45 → 227
      nt_trans; nucleotidyl transferase superfamily
      cl12020
      Location:856 → 905
      Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      57327430..57397990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005209538.5 → XP_005209595.2  leucine--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A3Q1N108, A0AAA9TPM1
      Related
      ENSBTAP00070046038.1, ENSBTAT00070075421.1
      Conserved Domains (1) summary
      cl26128
      Location:5 → 1062
      tRNA-synt_1g; tRNA synthetases class I (M)
    Nucleotide Protein Strain
    Heading Accession and Version

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