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    kipf kipferl [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kipfprovided by FlyBase
    Official Full Name
    kipferlprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014931
    Locus tag
    Dmel_CG2678
    See related
    AllianceGenome:FB:FBgn0014931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-84Eb; B; CG2678; Dmel\CG2678; Kipf
    Summary
    Enables chromatin DNA binding activity; chromatin-protein adaptor activity; and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of piRNA transcription. Located in cytosol. Is expressed in adult brain cell body rind and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kipf in Genome Data Viewer
    Location:
    84E5-84E5; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7913851..7916550)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3739573..3742272)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase Neighboring gene Riboflavin kinase Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene lodestar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic control of a sex-specific piRNA program. Chen P, et al. Curr Biol, 2023 May 8. PMID 37059098, Free PMC Article
    2. Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals. Baumgartner L, et al. Elife, 2024 Jul 12. PMID 38995818, Free PMC Article
    3. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham CH, et al. Genes Dev, 1991 Oct. PMID 1916263
    4. A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Baker BS, et al. Genes Dev, 1988 Apr. PMID 2453394
    5. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Clark DV. Genetics, 1994 Feb. PMID 8150282, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 7915828-7915889 mobile_element_type = transposon:INE-1{}1840

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin-protein adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of piRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kipferl
    Names
    CG2678-PA
    CG2678-PB
    kipf-PA
    kipf-PB
    transcript B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7913851..7916550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260044.2 → NP_001246973.1  kipferl, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7A6
      Conserved Domains (4) summary
      smart00868
      Location:8 → 85
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5048
      Location:220 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:249 → 271
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_141493.4 → NP_649750.1  kipferl, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D4G7A6, D4G7A7, O76205, Q8T053, Q9VHY3
      Related
      FBpp0081254
      Conserved Domains (4) summary
      smart00868
      Location:8 → 85
      zf-AD; Zinc-finger associated domain (zf-AD)
      COG5048
      Location:220 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:249 → 271
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4G7A6 D4G7A6
    Q8T053.1 Q8T053

    Gene LinkOut

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