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    MGA MAX dimerization protein MGA [ Bos taurus (domestic cattle) ]

    Gene ID: 532556, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MGAprovided by VGNC
    Official Full Name
    MAX dimerization protein MGAprovided by VGNC
    Primary source
    VGNC:VGNC:31445
    See related
    BGD:BT17152; Ensembl:ENSBTAG00000015138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See MGA in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (37019367..37168197)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene synaptosomal-associated protein 23-like Neighboring gene U6 spliceosomal RNA Neighboring gene large ribosomal subunit protein uL1-like Neighboring gene N-terminal kinase-like protein Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene microRNA mir-2285cr-1 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene jumonji domain containing 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAX gene-associated protein
    Names
    MAX gene associated
    MGA, MAX dimerization protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191402.1 → NP_001178331.1  MAX gene-associated protein

      See identical proteins and their annotated locations for NP_001178331.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      E1BKB7
      Related
      ENSBTAP00000020143.5, ENSBTAT00000020143.6
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2216 → 2266
      HLH; Helix-loop-helix DNA-binding domain
      pfam06752
      Location:1454 → 1567
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      37019367..37168197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997621.2 → XP_024853389.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2475 → 2525
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1558 → 1958
      Atrophin-1; Atrophin-1 family

    2. XM_059890463.1 → XP_059746446.1  MAX gene-associated protein isoform X12

      UniProtKB/TrEMBL
      E1BKB7

    3. XM_024997622.2 → XP_024853390.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2475 → 2525
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1558 → 1958
      Atrophin-1; Atrophin-1 family

    4. XM_024997618.2 → XP_024853386.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2475 → 2525
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1558 → 1958
      Atrophin-1; Atrophin-1 family

    5. XM_010809181.4 → XP_010807483.1  MAX gene-associated protein isoform X2

      See identical proteins and their annotated locations for XP_010807483.1

      UniProtKB/TrEMBL
      A0AAA9SD33, E1BKB7
      Related
      ENSBTAP00000083313.1, ENSBTAT00000119274.1
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2474 → 2524
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)

    6. XM_024997627.2 → XP_024853395.1  MAX gene-associated protein isoform X7

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2305 → 2355
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1530 → 1788
      Atrophin-1; Atrophin-1 family

    7. XM_024997628.2 → XP_024853396.1  MAX gene-associated protein isoform X8

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2266 → 2316
      HLH; Helix-loop-helix DNA-binding domain

    8. XM_024997624.2 → XP_024853392.1  MAX gene-associated protein isoform X3

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2426 → 2476
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1467 → 1909
      Atrophin-1; Atrophin-1 family

    9. XM_010809185.4 → XP_010807487.1  MAX gene-associated protein isoform X4

      See identical proteins and their annotated locations for XP_010807487.1

      UniProtKB/TrEMBL
      A0AAA9SHD9, E1BKB7
      Related
      ENSBTAP00000081918.1, ENSBTAT00000098173.1
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2425 → 2475
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)

    10. XM_010809191.4 → XP_010807493.1  MAX gene-associated protein isoform X9

      See identical proteins and their annotated locations for XP_010807493.1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2216 → 2266
      HLH; Helix-loop-helix DNA-binding domain
      pfam06752
      Location:1454 → 1567
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)

    11. XM_059890465.1 → XP_059746448.1  MAX gene-associated protein isoform X13

    12. XM_024997625.2 → XP_024853393.1  MAX gene-associated protein isoform X5

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2365 → 2415
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1448 → 1848
      Atrophin-1; Atrophin-1 family

    13. XM_024997626.2 → XP_024853394.1  MAX gene-associated protein isoform X6

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2316 → 2366
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1399 → 1799
      Atrophin-1; Atrophin-1 family

    14. XM_059890466.1 → XP_059746449.1  MAX gene-associated protein isoform X14

    15. XM_024997630.2 → XP_024853398.1  MAX gene-associated protein isoform X12

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (3) summary
      pfam16059
      Location:585 → 631
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2019 → 2069
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1102 → 1502
      Atrophin-1; Atrophin-1 family

    16. XM_024997623.2 → XP_024853391.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2475 → 2525
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1558 → 1958
      Atrophin-1; Atrophin-1 family

    17. XM_059890467.1 → XP_059746450.1  MAX gene-associated protein isoform X15

    18. XM_059890469.1 → XP_059746452.1  MAX gene-associated protein isoform X17

    19. XM_059890472.1 → XP_059746455.1  MAX gene-associated protein isoform X18

    20. XM_059890471.1 → XP_059746454.1  MAX gene-associated protein isoform X18

    21. XM_059890468.1 → XP_059746451.1  MAX gene-associated protein isoform X16

    22. XM_059890470.1 → XP_059746453.1  MAX gene-associated protein isoform X18

    23. XM_059890473.1 → XP_059746456.1  MAX gene-associated protein isoform X19

    24. XM_024997619.2 → XP_024853387.1  MAX gene-associated protein isoform X1

      UniProtKB/TrEMBL
      E1BKB7
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1041 → 1087
      DUF4801; Domain of unknown function (DUF4801)
      pfam00010
      Location:2475 → 2525
      HLH; Helix-loop-helix DNA-binding domain
      cl26464
      Location:1558 → 1958
      Atrophin-1; Atrophin-1 family

    25. XM_059890464.1 → XP_059746447.1  MAX gene-associated protein isoform X12

      UniProtKB/TrEMBL
      E1BKB7

    26. XM_059890461.1 → XP_059746444.1  MAX gene-associated protein isoform X10

      UniProtKB/TrEMBL
      E1BKB7

    27. XM_059890462.1 → XP_059746445.1  MAX gene-associated protein isoform X11

      UniProtKB/TrEMBL
      E1BKB7
    Nucleotide Protein Strain
    Heading Accession and Version

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