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    CtsF Cathepsin F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsFprovided by FlyBase
    Official Full Name
    Cathepsin Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260462
    Locus tag
    Dmel_CG12163
    See related
    AllianceGenome:FB:FBgn0260462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.305; CG12163; Cts8; Cts9; CTSF; Dmel\CG12163
    Old locus tag
    CG12163
    Summary
    Enables cysteine-type peptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in fusome. Is expressed in several structures, including adult brain; adult brain cell body rind; adult gnathal ganglion; adult head; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 13. Orthologous to human CTSF (cathepsin F). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsF in Genome Data Viewer
    Location:
    82F6-82F7; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5237651..5251745, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1063373..1077467, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 37B Neighboring gene Katanin 60 Neighboring gene Mms19 Neighboring gene retinophilin Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44019 Neighboring gene uncharacterized protein Neighboring gene Enolase-phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cp1/cathepsin L is required for autolysosomal clearance in Drosophila. Xu T, et al. Autophagy, 2021 Oct. PMID 33112206, Free PMC Article
    2. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
    3. Drosophila retinophilin contains MORN repeats and is conserved in humans. Mecklenburg KL. Mol Genet Genomics, 2007 May. PMID 17285308
    4. Dependence on a retinophilin/myosin complex for stability of PKC and INAD and termination of phototransduction. Venkatachalam K, et al. J Neurosci, 2010 Aug 25. PMID 20739554, Free PMC Article
    5. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perivitelline space HDA PubMed 

    General protein information

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    Preferred Names
    cathepsin F
    Names
    CG12163-PA
    CG12163-PB
    CG12163-PC
    CtsF-PA
    CtsF-PB
    CtsF-PC
    NP_649521.1
    NP_730901.1
    NP_730902.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5237651..5251745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141264.4 → NP_649521.1  cathepsin F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8F3
      Related
      FBpp0078464
      Conserved Domains (3) summary
      cd02248
      Location:256 → 472
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:169 → 226
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cl09238
      Location:55 → 133
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    2. NM_169033.4 → NP_730901.1  cathepsin F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q867H7, Q9VN92, Q9VN93
      Related
      FBpp0078465
      Conserved Domains (3) summary
      cd02248
      Location:395 → 611
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:308 → 365
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      cl09238
      Location:194 → 272
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    3. NM_169034.4 → NP_730902.2  cathepsin F, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730902.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PK81
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3PK81 D3PK81
    Q9VN93.2 Q9VN93

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