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    MIC1 major histocompatibility class I related protein [ Bos taurus (domestic cattle) ]

    Gene ID: 533051, updated on 27-Dec-2024

    Summary

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    Gene symbol
    MIC1
    Gene description
    major histocompatibility class I related protein
    See related
    BGD:BT12102; Ensembl:ENSBTAG00000010166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    MIC; MIC3; Bota-MIC1
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    Genomic context

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    See MIC1 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (27905419..27917017, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I, A Neighboring gene MHC class I heavy chain Neighboring gene BOLA class I histocompatibility antigen, alpha chain BL3-7-like Neighboring gene MHC class I polypeptide-related sequence B Neighboring gene POU class 5 homeobox 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Non-classical major histocompatibility complex class makes a crucial contribution to reproduction in the dairy cow. Shu L, et al. J Reprod Dev, 2012. PMID 22785322
    2. Genomic location and characterisation of MIC genes in cattle. Birch J, et al. Immunogenetics, 2008 Aug. PMID 18548244
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide antigen binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility class I related protein
    Names
    MHC class I polypeptide-related sequence B-like
    MHC class I-related chain
    MHC class I-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425177.1 → NP_001412106.1  major histocompatibility class I related protein precursor

      Status: VALIDATED

      Source sequence(s)
      NKLS02000023
      UniProtKB/TrEMBL
      B2MWQ4

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27905419..27917017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059880386.1 → XP_059736369.1  major histocompatibility class I related protein isoform X1

      UniProtKB/TrEMBL
      F1MJW2

    2. XM_024983642.2 → XP_024839410.1  major histocompatibility class I related protein isoform X2

      UniProtKB/TrEMBL
      B2MWQ4
      Related
      ENSBTAP00000013413.6, ENSBTAT00000013413.7
      Conserved Domains (1) summary
      cl08246
      Location:24 → 189
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. XM_015459891.3 → XP_015315377.1  major histocompatibility class I related protein isoform X1

      UniProtKB/TrEMBL
      F1MJW2
      Conserved Domains (1) summary
      cl08246
      Location:40 → 205
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001127317.1: Suppressed sequence

      Description
      NM_001127317.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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