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    LManII Lysosomal alpha-mannosidase II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LManIIprovided by FlyBase
    Official Full Name
    Lysosomal alpha-mannosidase IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027611
    Locus tag
    Dmel_CG6206
    See related
    AllianceGenome:FB:FBgn0027611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02419; CG6206; dLM; dLM408; dLManII; dLMII; Dmel\CG6206; LM; LM408
    Summary
    Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; central brain anlage in statu nascendi; and mesoderm. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LManII in Genome Data Viewer
    Location:
    31E5-31E5; 2-42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10457658..10462472)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10457658..10462472)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pickpocket 10 Neighboring gene Lysosomal alpha-mannosidase I Neighboring gene RluA pseudouridine synthase 1 Neighboring gene RluA pseudouridine synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and preliminary crystallographic analysis of Drosophila melanogaster lysosomal α-mannosidase. Nemčovičová I, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Aug 1. PMID 22869134, Free PMC Article
    2. Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. Kuntz DA, et al. Biochemistry, 2008 Sep 23. PMID 18759458
    3. 1,4-Dideoxy-1,4-imino-D- and L-lyxitol-based inhibitors bind to Golgi α-mannosidase II in different protonation forms. Kóňa J, et al. Org Biomol Chem, 2022 Nov 23. PMID 36322142, Free PMC Article
    4. α-D-mannose derivatives as models designed for selective inhibition of Golgi α-mannosidase II. Poláková M, et al. Eur J Med Chem, 2011 Mar. PMID 21295890
    5. Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and mannosidases. Brissonnet Y, et al. J Am Chem Soc, 2013 Dec 11. PMID 24224682

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. plate-shaped crystals of lysosomal alpha-mannosidase exhibited the symmetry of space group P2(1)2(1)2(1) and diffracted to a minimum d-spacing of 3.5 A
      Title: Expression, purification and preliminary crystallographic analysis of Drosophila melanogaster lysosomal α-mannosidase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal alpha-mannosidase II
    Names
    CG6206-PA
    CG6206-PB
    LManII-PA
    LManII-PB
    class II lysosomal alpha-mannosidase
    lysosomal alpha-mannosidase
    lysosomal mannosidase
    NP_609408.1
    NP_723591.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10457658..10462472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135564.4 → NP_609408.1  lysosomal alpha-mannosidase II, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKV1, Q9Y167
      Related
      FBpp0079620
      Conserved Domains (3) summary
      cd10810
      Location:47 → 323
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:370 → 445
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:502 → 957
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    2. NM_164929.2 → NP_723591.1  lysosomal alpha-mannosidase II, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPB7
      Related
      FBpp0079621
      Conserved Domains (3) summary
      cd10810
      Location:47 → 323
      GH38N_AMII_LAM_like; N-terminal catalytic domain of lysosomal alpha-mannosidase and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:370 → 445
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:502 → 957
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPB7 Q8IPB7
    Q9VKV1 Q9VKV1

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