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    Sf3a1 Splicing factor 3a subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42048, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3a1provided by FlyBase
    Official Full Name
    Splicing factor 3a subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0266917
    Locus tag
    Dmel_CG16941
    See related
    AllianceGenome:FB:FBgn0266917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16941; Dmel\CG16941; l(2)SH3 146; l(3)SH146; sf3a1; SF3a1; SF3A1; SF3a120
    Summary
    Predicted to enable RNA binding activity. Involved in spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sf3a1 in Genome Data Viewer
    Location:
    89E6-89E7; 3-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16999384..17002355, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12825106..12828077, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45213 Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit 2A Neighboring gene uncharacterized protein Neighboring gene Immune-regulated catalase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Wu H, et al. Proc Natl Acad Sci U S A, 2016 Apr 12. PMID 27035939, Free PMC Article
    2. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Chung CY, et al. Nat Commun, 2018 Oct 23. PMID 30353006, Free PMC Article
    3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    4. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    5. Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo. Shimaji K, et al. Exp Cell Res, 2016 Aug 1. PMID 27343629

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    splicing factor 3a subunit 1
    Names
    CG16941-PA
    Sf3a1-PA
    lethal (3) SH146
    splicing factor 3a, subunit 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16999384..17002355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142326.3 → NP_650583.1  splicing factor 3a subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEP9
      Related
      FBpp0082817
      Conserved Domains (5) summary
      cd01800
      Location:709 → 784
      SF3a120_C; Ubiquitin-like domain of Mammalian splicing factor SF3a_120
      smart00648
      Location:36 → 89
      SWAP; Suppressor-of-White-APricot splicing regulator
      smart00213
      Location:713 → 777
      UBQ; Ubiquitin homologues
      pfam01805
      Location:150 → 200
      Surp; Surp module
      pfam12230
      Location:227 → 479
      PRP21_like_P; Pre-mRNA splicing factor PRP21 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEP9 Q9VEP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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