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    GRK3 G protein-coupled receptor kinase 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 282136, updated on 30-Jan-2025

    Summary

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    Official Symbol
    GRK3provided by VGNC
    Official Full Name
    G protein-coupled receptor kinase 3provided by VGNC
    Primary source
    VGNC:VGNC:53904
    See related
    BGD:BT12296; EnsemblRapid:ENSBTAG00070019566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ADRBK2
    Orthologs
    human mouse all
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    Genomic context

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    See GRK3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (65389718..65510769)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112442007 Neighboring gene uncharacterized LOC132342638 Neighboring gene myosin XVIIIB Neighboring gene microRNA mir-10020 Neighboring gene uncharacterized LOC112442055

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers. Hollins B, et al. Cell Signal, 2009 Jun. PMID 19258039, Free PMC Article
    2. Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. Benovic JL, et al. J Biol Chem, 1991 Aug 15. PMID 1869533
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables G protein-coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in desensitization of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein-coupled receptor kinase 3
    Names
    adrenergic, beta, receptor kinase 2
    beta-ARK-2
    beta-adrenergic receptor kinase 2
    NP_776925.1
    XP_024832784.1
    XP_059731866.1
    XP_059731867.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174500.2 → NP_776925.1  G protein-coupled receptor kinase 3

      See identical proteins and their annotated locations for NP_776925.1

      Status: PROVISIONAL

      Source sequence(s)
      M73216
      UniProtKB/Swiss-Prot
      P26818
      UniProtKB/TrEMBL
      A0AAF6YGR0
      Related
      ENSBTAP00070026633.1, ENSBTAT00070044229.1
      Conserved Domains (5) summary
      cd08747
      Location:30 → 186
      RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)
      cd01240
      Location:553 → 670
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cd05633
      Location:185 → 530
      STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
      pfam00069
      Location:191 → 453
      Pkinase; Protein kinase domain
      pfam00169
      Location:562 → 647
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65389718..65510769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977016.2 → XP_024832784.1  G protein-coupled receptor kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LVI8, A0AAF6YGR0
      Related
      ENSBTAP00070026639.1, ENSBTAT00070044241.1
      Conserved Domains (3) summary
      cd01240
      Location:515 → 632
      PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain
      cd05633
      Location:147 → 492
      STKc_GRK3; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3
      cl02565
      Location:30 → 147
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_059875883.1 → XP_059731866.1  G protein-coupled receptor kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T431

    3. XM_059875884.1 → XP_059731867.1  G protein-coupled receptor kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9T431
      Related
      ENSBTAP00070026611.1, ENSBTAT00070044188.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26818.1 GenPept UniProtKB/Swiss-Prot:P26818

    Gene LinkOut

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