Loxl2 Lysyl oxidase-like 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Loxl2provided by FlyBase
Official Full Name: Lysyl oxidase-like 2provided by FlyBase
Primary source: FLYBASE:FBgn0034660
Locus tag: Dmel_CG4402
See related: AllianceGenome:FB:FBgn0034660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4402; Dmel\CG4402; dmlox-2; Dmloxl-2; LOX; lox2
Summary: Predicted to enable protein-lysine 6-oxidase activity. Predicted to be involved in protein modification process. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in organism. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; myopia; and primary open angle glaucoma. Orthologous to several human genes including LOXL3 (lysyl oxidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21789623..21791580, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17677128..17679085, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development
Title: Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development.

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Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEA Inferred from Electronic Annotation more info
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in protein modification process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_523806.2

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The following sections contain reference sequences that belong to a specific genome build. Explain