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    Culd CUB and LDLa domain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Culdprovided by FlyBase
    Official Full Name
    CUB and LDLa domainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035880
    Locus tag
    Dmel_CG17352
    See related
    AllianceGenome:FB:FBgn0035880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg17352; CG17352; CT33100; culd; CULD; Dmel\CG17352
    Summary
    Involved in endocytosis; photoreceptor cell maintenance; and rhodopsin metabolic process. Located in early endosome. Is expressed in Bolwig organ; Bolwig organ primordium; adult head; eye; and photoreceptor neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Culd in Genome Data Viewer
    Location:
    66C8-66C8; 3-24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8352355..8356296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8345455..8349396, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GTPase activating protein and centrosome-associated Neighboring gene mir-4913 stem loop Neighboring gene Isocitrate dehydrogenase Neighboring gene Ecdysone-inducible gene E1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). Yang J, et al. PLoS Genet, 2017 Aug. PMID 28827794, Free PMC Article
    2. Membrane protein trafficking in Drosophila photoreceptor cells. Schopf K, et al. Eur J Cell Biol, 2017 Aug. PMID 27964885
    3. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article
    4. Application of Fluorescent Proteins for Functional Dissection of the Drosophila Visual System. Smylla TK, et al. Int J Mol Sci, 2021 Aug 19. PMID 34445636, Free PMC Article
    5. Vitamin A deficiency affects gene expression in the Drosophila melanogaster head. Dewett D, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849795, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG17352 (CULD) plays an important role in the endocytic turnover of Rh1 and TRPL.
      Title: CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhodopsin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CUB and LDLa domain
    Names
    CG17352-PA
    CG17352-PB
    CG17352-PC
    CG17352-PE
    CUB- and LDLa- domain
    Culd-PA
    Culd-PB
    Culd-PC
    Culd-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8352355..8356296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168263.1 → NP_729364.1  CUB and LDLa domain, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6PBV8, Q8IQA9
      Related
      FBpp0076397, FBtr0076674
      Conserved Domains (2) summary
      cd00041
      Location:200 → 298
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:442 → 472
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. NM_168264.1 → NP_729365.1  CUB and LDLa domain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSI3
      Related
      FBpp0076398, FBtr0076675
      Conserved Domains (2) summary
      cd00041
      Location:200 → 298
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:442 → 472
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    3. NM_001104080.2 → NP_001097550.1  CUB and LDLa domain, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN6

    4. NM_139957.3 → NP_648214.2  CUB and LDLa domain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648214.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQA8
      Related
      FBpp0076399
      Conserved Domains (2) summary
      cd00041
      Location:200 → 298
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:442 → 472
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNN6 A8JNN6
    Q86P86 Q86P86
    Q8IQA8 Q8IQA8
    Q8IQA9 Q8IQA9
    Q95TB1 Q95TB1
    Q9VSI3 Q9VSI3

    Gene LinkOut

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