P4HTM prolyl 4-hydroxylase, transmembrane [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: P4HTMprovided by VGNC
Official Full Name: prolyl 4-hydroxylase, transmembraneprovided by VGNC
Primary source: VGNC:VGNC:32539
See related: BGD:BT29225; Ensembl:ENSBTAG00000005490
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: PH-4
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (50983769..50997485, complement)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transmembrane prolyl 4-hydroxylase

Names: hypoxia-inducible factor prolyl 4-hydroxylase

NP_001069583.1

EC 1.14.11.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076115.2 → NP_001069583.1 transmembrane prolyl 4-hydroxylase

See identical proteins and their annotated locations for NP_001069583.1

Status: PROVISIONAL

Source sequence(s)

BC114843

UniProtKB/TrEMBL

F1N3W9, Q1RMK7

Related

ENSBTAP00000007217.6, ENSBTAT00000007217.6

Conserved Domains (2) summary

smart00702
Location:238 → 450

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

cl08302
Location:192 → 244

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...