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    hmw hemingway [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42207, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hmwprovided by FlyBase
    Official Full Name
    hemingwayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038607
    Locus tag
    Dmel_CG7669
    See related
    AllianceGenome:FB:FBgn0038607
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.198; CG7669; Dmel\CG7669
    Summary
    Involved in detection of mechanical stimulus involved in sensory perception of sound; sperm axoneme assembly; and sperm individualization. Is expressed in Johnston organ neurons; chordotonal neurons; spermatid; and spermatocyte. Orthologous to human CFAP97 (cilia and flagella associated protein 97). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hmw in Genome Data Viewer
    Location:
    91A3-91A3; 3-63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18361994..18364277)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14187716..14189999)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45634 Neighboring gene WRN exonuclease Neighboring gene Nucleoporin 43kD Neighboring gene glass

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. hemingway is required for sperm flagella assembly and ciliary motility in Drosophila. Soulavie F, et al. Mol Biol Cell, 2014 Apr. PMID 24554765, Free PMC Article
    2. Imaging cilia in Drosophila melanogaster. Vieillard J, et al. Methods Cell Biol, 2015. PMID 25837397
    3. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
    4. Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression. Doggett K, et al. Dev Biol, 2011 Jul 15. PMID 21570388, Free PMC Article
    5. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hemingway
    Names
    CG7669-PA
    Hmw
    hmw-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18361994..18364277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142457.3 → NP_650714.1  hemingway [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0T7, Q9VE87
      Related
      FBpp0082997
      Conserved Domains (1) summary
      pfam13879
      Location:504 → 594
      KIAA1430; KIAA1430 homologue
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE87.2 Q9VE87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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