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    Tps1 Trehalose-6-phosphate synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tps1provided by FlyBase
    Official Full Name
    Trehalose-6-phosphate synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027560
    Locus tag
    Dmel_CG4104
    See related
    AllianceGenome:FB:FBgn0027560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    19920676; BcDNA:GH08860; CG4104; CG4104 PA; Dmel\CG4104; DmTPS1; dtps1; dTps1; jf5; l(2)24Ea; l(2)jf4; l(2)jf5; l(2)k08903; tps; TPS; tps1; TreS
    Summary
    Enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity and trehalose-phosphatase activity. Involved in trehalose biosynthetic process. Predicted to be located in cytoplasm. Is expressed in adult head; adult heart; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Tps1 in Genome Data Viewer
    Location:
    24E4-24E5; 2-12 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4388327..4392778)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4388327..4392778)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 53 Neighboring gene Partner of Sld Five 2 Neighboring gene uncharacterized protein Neighboring gene lethal (2) k05819 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Feala JD, et al. Ann N Y Acad Sci, 2008 Mar. PMID 18375589
    2. Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation. Thorat L, et al. Cell Stress Chaperones, 2016 Mar. PMID 26577464, Free PMC Article
    3. Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance. Chen Q, et al. J Biol Chem, 2003 Dec 5. PMID 13129920
    4. Trehalose-6-phosphate promotes fermentation and glucose repression in Saccharomyces cerevisiae. Vicente RL, et al. Microb Cell, 2018 Oct 1. PMID 30386789, Free PMC Article
    5. Eleven ancestral gene families lost in mammals and vertebrates while otherwise universally conserved in animals. Danchin EG, et al. BMC Evol Biol, 2006 Jan 18. PMID 16420703, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. both Tps1 and Treh mutant larvae exhibit a high lethality after desiccation stress. These results demonstrate that the regulation of trehalose metabolism is essential for normal development, body water homeostasis, and desiccation tolerance in Drosophila.
      Title: Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis.
    2. Insect trehalose synthesis is governed by the enzyme trehalose 6-phosphate synthase 1. Downregulation of Tps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.
      Title: Downregulation of dTps1 in Drosophila melanogaster larvae confirms involvement of trehalose in redox regulation following desiccation.
    3. These diet-dependent phenotypes of Tps1 mutants demonstrate the critical role of trehalose during development in Drosophila and reveal how animals adapt to changes in nutrient availability.
      Title: Flies without trehalose.
    4. role in increasing hypoxia tolerance in human cells
      Title: Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trehalose-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in trehalose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose metabolism in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Trehalose-6-phosphate synthase 1
    Names
    CG4104-PA
    Tps1-PA
    Trehalos-6-phosphate synthase
    Trehalose-6-phosphate phosphatase
    lethal(2)24Ea
    trehalose synthase
    trehalose-6-phosphate synthase
    trehalose-phosphate synthase
    NP_608827.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4388327..4392778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134983.3 → NP_608827.1  Trehalose-6-phosphate synthase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9Y119
      Related
      FBpp0077121
      Conserved Domains (3) summary
      cd03788
      Location:19 → 495
      GT1_TPS; Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a ...
      PRK14501
      Location:20 → 766
      PRK14501; putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional
      cl21460
      Location:530 → 770
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y119 Q9Y119

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