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    PPID peptidylprolyl isomerase D [ Bos taurus (domestic cattle) ]

    Gene ID: 281420, updated on 30-Jan-2025

    Summary

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    Official Symbol
    PPIDprovided by VGNC
    Official Full Name
    peptidylprolyl isomerase Dprovided by VGNC
    Primary source
    VGNC:VGNC:33197
    See related
    BGD:BT19985; EnsemblRapid:ENSBTAG00070017229
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CYP-40
    Annotation information
    Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by GeneID 414346, PPIF. [13 Feb 2013]
    Orthologs
    human mouse all
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    Genomic context

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    See PPID in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (40279452..40292371)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101904878 Neighboring gene mitochondrial carrier homolog 1-like Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene chromosome 17 C4orf46 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Two structures of cyclophilin 40: folding and fidelity in the TPR domains. Taylor P, et al. Structure, 2001 May 9. PMID 11377203
    2. The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59). Ratajczak T, et al. J Biol Chem, 1993 Jun 25. PMID 8514757
    3. Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome. Anderson S, et al. J Mol Biol, 1982 Apr 25. PMID 7120390
    4. Cyclophilin-40, a protein with homology to the P59 component of the steroid receptor complex. Cloning of the cDNA and further characterization. Kieffer LJ, et al. J Biol Chem, 1993 Jun 15. PMID 8509368
    5. Isolation and characterization of a 40-kDa cyclophilin-related protein. Kieffer LJ, et al. J Biol Chem, 1992 Mar 15. PMID 1544925

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC137782

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase D
    Names
    40 kDa peptidyl-prolyl cis-trans isomerase
    PPIase D
    cyclophilin-40
    cyclophilin-related protein
    estrogen receptor-binding cyclophilin
    peptidylprolyl isomerase D (cyclophilin D)
    rotamase D
    NP_776578.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174153.3 → NP_776578.1  peptidyl-prolyl cis-trans isomerase D

      See identical proteins and their annotated locations for NP_776578.1

      Status: PROVISIONAL

      Source sequence(s)
      BC113318
      UniProtKB/Swiss-Prot
      P26882, Q28077, Q2HJ45
      UniProtKB/TrEMBL
      A0AAA9TIX0
      Related
      ENSBTAP00070023020.1, ENSBTAT00070038827.1
      Conserved Domains (3) summary
      cd01926
      Location:16 → 182
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
      TIGR00990
      Location:192 → 362
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:223 → 267
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      40279452..40292371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26882.6 GenPept UniProtKB/Swiss-Prot:P26882

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