GlyRS Glycyl-tRNA synthetase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlyRSprovided by FlyBase
Official Full Name: Glycyl-tRNA synthetaseprovided by FlyBase
Primary source: FLYBASE:FBgn0027088
Locus tag: Dmel_CG6778
See related: AllianceGenome:FB:FBgn0027088
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aaRS(Gly); Aat-gly; Aats-gly; CG6778; dGars; dGARS; dGARS1; Dmel\CG6778; gars; Gars; GARS; GRS; team
Summary: Predicted to enable glycine-tRNA ligase activity. Involved in dendrite morphogenesis and larval lymph gland hemopoiesis. Located in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2; and Charcot-Marie-Tooth disease type 2D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 71B4-71B4; 3-42 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15095142..15097686)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15088242..15090786)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that mutant GlyRS gains access to ectopic sub-compartments of the motor neuron, providing a possible explanation for the selective neuropathology caused by mutations in a widely expressed gene.
Title: Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glycine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables glycine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in glycyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial glycyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Glycyl-tRNA synthetase

Names: CG6778-PA; CG6778-PB; CG6778-PC; GlyRS-PA; GlyRS-PB; GlyRS-PC; glycyl-tRNA synthetase; terminal arbors missing

NP_001261867.1

EC 6.1.1.-

EC 6.1.1.14

NP_648746.1

EC 6.1.1.-

EC 6.1.1.14

NP_730022.1

EC 6.1.1.-

EC 6.1.1.14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

15095142..15097686

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168605.2 → NP_730022.1 Glycyl-tRNA synthetase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730022.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C9QP25, Q961R8, Q9VUK8

Related

FBpp0075386

Conserved Domains (1) summary

PLN02734
Location:88 → 756

PLN02734; glycyl-tRNA synthetase
NM_001274938.1 → NP_001261867.1 Glycyl-tRNA synthetase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261867.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C9QP25, Q961R8, Q9VUK8

Conserved Domains (1) summary

PLN02734
Location:88 → 756

PLN02734; glycyl-tRNA synthetase
NM_140489.3 → NP_648746.1 Glycyl-tRNA synthetase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648746.1

Status: REVIEWED

UniProtKB/TrEMBL

Q961R8

Related

FBpp0075385

Conserved Domains (4) summary

PLN02734
Location:2 → 670

PLN02734; glycyl-tRNA synthetase

cd00774
Location:70 → 415

GlyRS-like_core; Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3' ...

cd00858
Location:535 → 642

GlyRS_anticodon; GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

cd00935
Location:10 → 60

GlyRS_RNA; GlyRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of GlyRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix-turn-helix structure , which is similar to other RNA-binding ...