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    Nadk2 NAD kinase 2, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nadk2provided by FlyBase
    Official Full Name
    NAD kinase 2, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033373
    Locus tag
    Dmel_CG8080
    See related
    AllianceGenome:FB:FBgn0033373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30346; CG8080; Dmel\CG8080; NADK2
    Summary
    Predicted to enable NAD+ kinase activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult brain; adult pars intercerebralis; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nadk2 in Genome Data Viewer
    Location:
    45A2-45A2; 2-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9089774..9092893, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4977279..4980398, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene ncRNA Neighboring gene Bootlegger Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis. Xu M, et al. Cell Rep, 2021 Dec 28. PMID 34965438
    2. Functional genomic analysis of the periodic transcriptome in the developing Drosophila wing. Liang L, et al. Dev Cell, 2014 Apr 14. PMID 24684830
    3. A gene-specific T2A-GAL4 library for Drosophila. Lee PT, et al. Elife, 2018 Mar 22. PMID 29565247, Free PMC Article
    4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NAD kinase 2, mitochondrial
    Names
    CG8080-PA
    CG8080-PB
    CG8080-PC
    CG8080-PD
    CG8080-PE
    Nadk2-PA
    Nadk2-PB
    Nadk2-PC
    Nadk2-PD
    Nadk2-PE
    NP_001260815.1
    NP_001260816.1
    NP_001260817.1
    NP_001260818.1
    NP_788288.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9089774..9092893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273887.2 → NP_001260816.1  NAD kinase 2, mitochondrial, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260816.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF27
      Conserved Domains (1) summary
      cl01255
      Location:106 → 283
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_176108.2 → NP_788288.1  NAD kinase 2, mitochondrial, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788288.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW73
      Related
      FBpp0087714
      Conserved Domains (1) summary
      cl01255
      Location:71 → 288
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. NM_001273886.1 → NP_001260815.1  NAD kinase 2, mitochondrial, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFF1
      Conserved Domains (1) summary
      cl01255
      Location:107 → 284
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. NM_001273888.1 → NP_001260817.1  NAD kinase 2, mitochondrial, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEH3
      Conserved Domains (1) summary
      cl01255
      Location:107 → 284
      DAGK_cat; Diacylglycerol kinase catalytic domain

    5. NM_001273889.1 → NP_001260818.1  NAD kinase 2, mitochondrial, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEG0
      Conserved Domains (1) summary
      cl01255
      Location:71 → 288
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEG0 A0A0B4KEG0
    A0A0B4KEH3 A0A0B4KEH3
    A0A0B4KF27 A0A0B4KF27
    A0A0B4KFF1 A0A0B4KFF1
    Q7JW73 Q7JW73

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