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    XRCC6 X-ray repair cross complementing 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 510132, updated on 1-Jan-2025

    Summary

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    Official Symbol
    XRCC6provided by VGNC
    Official Full Name
    X-ray repair cross complementing 6provided by VGNC
    Primary source
    VGNC:VGNC:37007
    See related
    Ensembl:ENSBTAG00000006103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See XRCC6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (112706840..112730021)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 1 Neighboring gene desumoylating isopeptidase 1 Neighboring gene small nuclear ribonucleoprotein 13 Neighboring gene uncharacterized LOC112446778

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ku70:Ku80 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    X-ray repair cross-complementing protein 6
    Names
    X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192246.1 → NP_001179175.1  X-ray repair cross-complementing protein 6

      See identical proteins and their annotated locations for NP_001179175.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000005
      UniProtKB/TrEMBL
      A0AAA9TL89
      Conserved Domains (1) summary
      TIGR00578
      Location:32 → 610
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      112706840..112730021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005207383.5 → XP_005207440.1  X-ray repair cross-complementing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005207440.1

      UniProtKB/TrEMBL
      A0AAA9TL89
      Related
      ENSBTAP00000008020.6, ENSBTAT00000008020.7
      Conserved Domains (1) summary
      TIGR00578
      Location:27 → 605
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    2. XM_005207382.5 → XP_005207439.1  X-ray repair cross-complementing protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005207439.1

      UniProtKB/TrEMBL
      A0AAA9TL89
      Related
      ENSBTAP00000092442.1, ENSBTAT00000088209.1
      Conserved Domains (1) summary
      TIGR00578
      Location:27 → 605
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    3. XM_010805746.3 → XP_010804048.1  X-ray repair cross-complementing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_010804048.1

      UniProtKB/TrEMBL
      A0AAA9TL89
      Conserved Domains (3) summary
      cd00788
      Location:256 → 531
      KU70; Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      cd01458
      Location:38 → 251
      vWA_ku; Ku70/Ku80 N-terminal domain. The Ku78 heterodimer (composed of Ku70 and Ku80) contributes to genomic integrity through its ability to bind DNA double-strand breaks (DSB) in a preferred orientation. DSB's are repaired by either homologues recombination or ...
      TIGR00578
      Location:32 → 558
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)

    4. XM_059886265.1 → XP_059742248.1  X-ray repair cross-complementing protein 6 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TL89

    5. XM_015471395.3 → XP_015326881.1  X-ray repair cross-complementing protein 6 isoform X3

      UniProtKB/TrEMBL
      A0AAA9TL89
      Conserved Domains (1) summary
      cl25384
      Location:1 → 560
      Ku_C; Ku70/Ku80 C-terminal arm
    Nucleotide Protein Strain
    Heading Accession and Version

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