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    TOP3B DNA topoisomerase III beta [ Bos taurus (domestic cattle) ]

    Gene ID: 537418, updated on 29-Jan-2025

    Summary

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    Official Symbol
    TOP3Bprovided by VGNC
    Official Full Name
    DNA topoisomerase III betaprovided by VGNC
    Primary source
    VGNC:VGNC:106991
    See related
    BGD:BT29985; Ensembl:ENSBTAG00000053372
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See TOP3B in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (71951333..71966904)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda like polypeptide 1 Neighboring gene V-set pre-B cell surrogate light chain 1 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1F Neighboring gene U6 spliceosomal RNA Neighboring gene mitogen-activated protein kinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA topological change IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA topoisomerase 3-beta-1
    Names
    topoisomerase (DNA) III beta
    NP_001193635.1
    XP_024833140.1
    XP_024833141.1
    XP_059732088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206706.2 → NP_001193635.1  DNA topoisomerase 3-beta-1

      Status: PROVISIONAL

      Source sequence(s)
      BT026532, CX735376, EE359622, EV701465, NKLS02000017
      UniProtKB/TrEMBL
      A0A3Q1LUZ8, A0AAA9T6F2
      Related
      ENSBTAP00070029880.1, ENSBTAT00070050137.1
      Conserved Domains (1) summary
      cl27598
      Location:3 → 752
      TOP1Bc; Bacterial DNA topoisomeraes I ATP-binding domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      71951333..71966904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977372.2 → XP_024833140.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUZ8, A0AAA9T6F2
      Conserved Domains (1) summary
      cl27598
      Location:3 → 752
      TOP1Bc; Bacterial DNA topoisomeraes I ATP-binding domain

    2. XM_059876105.1 → XP_059732088.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUZ8, A0AAA9T6F2

    3. XM_024977373.2 → XP_024833141.1  DNA topoisomerase 3-beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUZ8, A0AAA9T6F2
      Conserved Domains (1) summary
      cl27598
      Location:3 → 752
      TOP1Bc; Bacterial DNA topoisomeraes I ATP-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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