GSS glutathione synthetase [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GSSprovided by VGNC
Official Full Name: glutathione synthetaseprovided by VGNC
Primary source: VGNC:VGNC:29683
See related: BGD:BT15351; Ensembl:ENSBTAG00000003504
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	13	NC_037340.1 (64234179..64259465, complement)

Chromosome 13 - NC_037340.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PrP(c) is expressed in all digestive regions of the rat, monkey, and cow; PrP(c) expressing cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.
Title: Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.

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General gene information

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Markers

MARC_11817-11818:1029268323:1 (e-PCR)
- UniSTS:267270

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables glutathione binding	IEA Inferred from Electronic Annotation more info	PubMed
enables glutathione synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutathione synthetase

Names: GSH synthetase; GSH-S; glutathione synthase

NP_001015630.1

EC 6.3.2.3

XP_005214784.1

EC 6.3.2.3

XP_005214785.1

EC 6.3.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015630.1 → NP_001015630.1 glutathione synthetase

See identical proteins and their annotated locations for NP_001015630.1

Status: PROVISIONAL

Source sequence(s)

BT020647

UniProtKB/Swiss-Prot

Q2TBS8, Q5EAC2

UniProtKB/TrEMBL

A0AAA9TGU7

Related

ENSBTAP00000004559.3, ENSBTAT00000004559.4

Conserved Domains (1) summary

cd00228
Location:6 → 474

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

Range

64234179..64259465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005214728.5 → XP_005214785.1 glutathione synthetase isoform X2

See identical proteins and their annotated locations for XP_005214785.1

UniProtKB/TrEMBL

A0A140T850, A0AAA9TGU7

Related

ENSBTAP00000102070.1, ENSBTAT00000103666.1

Conserved Domains (1) summary

cd00228
Location:6 → 474

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
XM_005214727.5 → XP_005214784.1 glutathione synthetase isoform X1

UniProtKB/TrEMBL

A0AAA9S395, A0AAA9TS83

Related

ENSBTAP00000100201.1, ENSBTAT00000125032.1

Conserved Domains (1) summary

cd00228
Location:10 → 478

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.