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    Zip99C Zinc/iron regulated transporter-related protein 99C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zip99Cprovided by FlyBase
    Official Full Name
    Zinc/iron regulated transporter-related protein 99Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039714
    Locus tag
    Dmel_CG7816
    See related
    AllianceGenome:FB:FBgn0039714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7816; CG7816; Dmel\CG7816; dZip13; dZIP13; dZip99C; Zip13; ZIP13; ZIP99C
    Summary
    Enables iron ion binding activity and iron ion transmembrane transporter activity. Involved in detoxification of zinc ion; iron ion transport; and multicellular organismal-level iron ion homeostasis. Located in Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval crystal cell; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 3. Orthologous to human SLC39A13 (solute carrier family 39 member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zip99C in Genome Data Viewer
    Location:
    99C4-99C5; 3-99 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29863701..29868895, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25689423..25694617, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress caused by lead (Pb) induces iron deficiency in Drosophila melanogaster. Liu ZH, et al. Chemosphere, 2020 Mar. PMID 31995880
    2. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. Xiao G, et al. Elife, 2014 Jul 8. PMID 25006035, Free PMC Article
    3. Drosophila ZIP13 is posttranslationally regulated by iron-mediated stabilization. Xu J, et al. Biochim Biophys Acta Mol Cell Res, 2019 Sep. PMID 31229649
    4. Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Xiao G, et al. Cell Rep, 2019 Jan 15. PMID 30650364
    5. A distinctive sequence motif in the fourth transmembrane domain confers ZIP13 iron function in Drosophila melanogaster. Zhao M, et al. Biochim Biophys Acta Mol Cell Res, 2020 Feb. PMID 31733261

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.
      Title: The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of zinc ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc/iron regulated transporter-related protein 99C
    Names
    CG7816-PA
    CG7816-PC
    CG7816-PD
    CG7816-PE
    CG7816-PF
    CG7816-PG
    CG7816-PH
    CG7816-PI
    CG7816-PJ
    Zip99C-PA
    Zip99C-PC
    Zip99C-PD
    Zip99C-PE
    Zip99C-PF
    Zip99C-PG
    Zip99C-PH
    Zip99C-PI
    Zip99C-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29863701..29868895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202386.2 → NP_001189315.1  Zinc/iron regulated transporter-related protein 99C, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    2. NM_001202385.2 → NP_001189314.1  Zinc/iron regulated transporter-related protein 99C, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    3. NM_170444.3 → NP_733323.1  Zinc/iron regulated transporter-related protein 99C, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733323.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088864
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    4. NM_170445.2 → NP_733324.1  Zinc/iron regulated transporter-related protein 99C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088863
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    5. NM_170440.2 → NP_733319.1  Zinc/iron regulated transporter-related protein 99C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088862
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    6. NM_170442.2 → NP_733321.1  Zinc/iron regulated transporter-related protein 99C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088861
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    7. NM_001202384.1 → NP_001189313.1  Zinc/iron regulated transporter-related protein 99C, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    8. NM_170443.3 → NP_733322.1  Zinc/iron regulated transporter-related protein 99C, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088860
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter

    9. NM_170441.2 → NP_733320.1  Zinc/iron regulated transporter-related protein 99C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YH2, Q9VAF0
      UniProtKB/TrEMBL
      A4V3L8
      Related
      FBpp0088859
      Conserved Domains (1) summary
      pfam02535
      Location:34 → 350
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V3L8 A4V3L8
    Q95T93 Q95T93
    Q9VAF0.1 Q9VAF0

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