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    ARHGEF28 Rho guanine nucleotide exchange factor 28 [ Bos taurus (domestic cattle) ]

    Gene ID: 616969, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ARHGEF28provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 28provided by VGNC
    Primary source
    VGNC:VGNC:26114
    See related
    BGD:BT13068; Ensembl:ENSBTAG00000005633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    RGNEF
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF28 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (7683040..8027709, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112443077 Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene enhancer of rudimentary homolog Neighboring gene synaptopodin 2-like protein Neighboring gene UTP15 small subunit processome component Neighboring gene ankyrin repeat family A member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC154970

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 28
    Names
    190 kDa guanine nucleotide exchange factor
    Rho guanine nucleotide exchange factor (GEF) 28
    Rho-guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102307.1 → NP_001095777.2  rho guanine nucleotide exchange factor 28

      Status: VALIDATED

      Source sequence(s)
      BC149175
      UniProtKB/TrEMBL
      A0A3Q1LIP3, A6QP67
      Related
      ENSBTAP00000058978.1, ENSBTAT00000068151.1
      Conserved Domains (4) summary
      smart00325
      Location:539 → 728
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:339 → 384
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:809 → 874
      PH; PH domain
      cl17171
      Location:773 → 873
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7683040..8027709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878798.1 → XP_059734781.1  rho guanine nucleotide exchange factor 28 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M605

    2. XM_059878797.1 → XP_059734780.1  rho guanine nucleotide exchange factor 28 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M605

    3. XM_059878796.1 → XP_059734779.1  rho guanine nucleotide exchange factor 28 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1M605
      Related
      ENSBTAP00000080323.1, ENSBTAT00000109059.1

    4. XM_059878794.1 → XP_059734777.1  rho guanine nucleotide exchange factor 28 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1M605, A0AAA9TYA4
      Related
      ENSBTAP00000101651.1, ENSBTAT00000131907.1

    5. XM_059878793.1 → XP_059734776.1  rho guanine nucleotide exchange factor 28 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LKT3, A0A3Q1M605
      Related
      ENSBTAP00000060264.2, ENSBTAT00000074225.2

    6. XM_059878795.1 → XP_059734778.1  rho guanine nucleotide exchange factor 28 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1M605

    7. XM_024981402.2 → XP_024837170.1  rho guanine nucleotide exchange factor 28 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1N4R7
      Related
      ENSBTAP00000064850.2, ENSBTAT00000072317.2
      Conserved Domains (5) summary
      cd00029
      Location:656 → 701
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:853 → 1045
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:203 → 265
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl17171
      Location:1090 → 1190
      PH-like; Pleckstrin homology-like domain
      cl25742
      Location:1427 → 1565
      ERM; Ezrin/radixin/moesin family

    8. XM_024981401.2 → XP_024837169.1  rho guanine nucleotide exchange factor 28 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M605
      Conserved Domains (5) summary
      cd00029
      Location:694 → 739
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:891 → 1083
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00204
      Location:203 → 265
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl17171
      Location:1128 → 1228
      PH-like; Pleckstrin homology-like domain
      cl25742
      Location:1465 → 1603
      ERM; Ezrin/radixin/moesin family

    9. XM_059878799.1 → XP_059734782.1  rho guanine nucleotide exchange factor 28 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1M605

    10. XM_024981396.2 → XP_024837164.2  rho guanine nucleotide exchange factor 28 isoform X11

      UniProtKB/TrEMBL
      A6QP67

    11. XM_024981400.2 → XP_024837168.2  rho guanine nucleotide exchange factor 28 isoform X9

      UniProtKB/TrEMBL
      A6QP67

    12. XM_059878801.1 → XP_059734784.1  rho guanine nucleotide exchange factor 28 isoform X10

      UniProtKB/TrEMBL
      A6QP67, F1N482
      Related
      ENSBTAP00000007406.7, ENSBTAT00000007406.7

    13. XM_059878800.1 → XP_059734783.1  rho guanine nucleotide exchange factor 28 isoform X8

      UniProtKB/TrEMBL
      A0A3Q1M605

    RNA

    1. XR_009491884.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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