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    pio piopio [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pioprovided by FlyBase
    Official Full Name
    piopioprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020521
    Locus tag
    Dmel_CG3541
    See related
    AllianceGenome:FB:FBgn0020521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30167; CG3541; Dmel\CG3541; Pio
    Summary
    Involved in several processes, including apposition of dorsal and ventral imaginal disc-derived wing surfaces; chitin-based cuticle attachment to epithelium; and chitin-based embryonic cuticle biosynthetic process. Located in apical part of cell. Is expressed in tracheal lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pio in Genome Data Viewer
    Location:
    60D7-60D8; 2-107 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24581245..24597862)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20468768..20485385)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Start1 Neighboring gene uncharacterized protein Neighboring gene SIFamide Neighboring gene uncharacterized protein Neighboring gene ATP synthase, subunit F Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tubulogenesis: zipping up your fly. Paul SM, et al. Curr Biol, 2005 Jan 26. PMID 15668162
    2. Watching tubules glow and branch. Davies JA. Curr Opin Genet Dev, 2005 Aug. PMID 15964757
    3. Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Jaźwińska A, et al. Nat Cell Biol, 2003 Oct. PMID 12973360
    4. Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. Baer MM, et al. J Cell Sci, 2012 Dec 15. PMID 23132924
    5. Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin. JayaNandanan N, et al. Nat Commun, 2014. PMID 24413568, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
      Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle attachment to epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based embryonic cuticle biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    piopio
    Names
    CG3541-PB
    CG3541-PC
    CG3541-PD
    CG3541-PE
    pio-PB
    pio-PC
    pio-PD
    pio-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24581245..24597862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169824.2 → NP_001163295.1  piopio, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRK0
      Conserved Domains (2) summary
      smart00241
      Location:66 → 349
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:248 → 349
      Zona_pellucida; Zona pellucida-like domain

    2. NM_166677.3 → NP_726461.1  piopio, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRK0
      Related
      FBpp0072219
      Conserved Domains (2) summary
      smart00241
      Location:66 → 349
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:248 → 349
      Zona_pellucida; Zona pellucida-like domain

    3. NM_138094.4 → NP_611938.2  piopio, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W143
      Related
      FBpp0072220

    4. NM_001299920.1 → NP_001286849.1  piopio, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRK0
      Conserved Domains (2) summary
      smart00241
      Location:66 → 349
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:248 → 349
      Zona_pellucida; Zona pellucida-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRK0 Q8IRK0
    Q95T91 Q95T91
    Q9W143 Q9W143

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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