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    CG40486 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG40486provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263830
    Locus tag
    Dmel_CG40486
    See related
    AllianceGenome:FB:FBgn0263830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12466; Dmel\CG40486; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult fat body. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG40486 in Genome Data Viewer
    Location:
    20F3-20F3; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22958856..22960091, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22360692..22361927, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene long non-coding RNA:CR45502 Neighboring gene uncharacterized protein Neighboring gene stoned A Neighboring gene stoned B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome. Bergman CM, et al. Genome Biol, 2006. PMID 17134480, Free PMC Article
    2. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
    3. Pilot RNAi Screen in Drosophila Neural Stem Cell Lineages to Identify Novel Tumor Suppressor Genes Involved in Asymmetric Cell Division. Manzanero-Ortiz S, et al. Int J Mol Sci, 2021 Oct 20. PMID 34768763, Free PMC Article
    4. A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome. Yandell M, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15668397, Free PMC Article
    5. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c22959359-22959290 mobile_element_type = transposon:INE-1{}3857

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-keto sterol reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG40486-PB
    CG40486-PC
    NP_001036311.2
    NP_001036312.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22958856..22960091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042846.3 → NP_001036311.2  uncharacterized protein Dmel_CG40486, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036311.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJT3
      Conserved Domains (2) summary
      COG4221
      Location:1 → 247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001042847.3 → NP_001036312.1  uncharacterized protein Dmel_CG40486, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036312.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJT3
      Conserved Domains (2) summary
      COG4221
      Location:1 → 247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5LJT3 Q5LJT3

    Gene LinkOut

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