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    pn prune [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pnprovided by FlyBase
    Official Full Name
    pruneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003116
    Locus tag
    Dmel_CG3461
    See related
    AllianceGenome:FB:FBgn0003116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3461; Dmel\CG3461; EG:152A3.5; N3; N4; TcD37
    Summary
    Enables cyclic-nucleotide phosphodiesterase activity. Involved in compound eye pigmentation; negative regulation of cAMP-mediated signaling; and pteridine metabolic process. Is active in mitochondrial matrix. Is expressed in organism. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    2E1-2E1; 1-0.8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2181211..2182916)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2075244..2076949)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1 Neighboring gene Nonsense-mediated mRNA 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics. Scoma ER, et al. Int J Mol Sci, 2023 Sep 8. PMID 37762163, Free PMC Article
    2. PAPER CHROMATOGRAPHY OF PTERIDINES OF PRUNE AND CLOT STOCKS OF DROSOPHILA MELANOGASTER. NARAYANAN Y, et al. Genetics, 1964 Sep. PMID 14207705, Free PMC Article
    3. [Transcription of the prune gene during a position effect of the mosaic type in Drosophila melanogaster]. Frolov MV, et al. Genetika, 1993 Sep. PMID 8276226
    4. [Region of the prune locus in Drosophila melanogaster is transcriptionally saturated]. Frolov MV, et al. Genetika, 1993 Sep. PMID 8276217
    5. The mRNA product of the Drosophila gene prune is spliced and encodes a protein containing a putative transmembrane domain. Frolov MV, et al. Mol Gen Genet, 1994 Feb. PMID 8121405

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
      Title: The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclic-nucleotide phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cAMP/PKA signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pteridine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prune
    Names
    CG3461-PA
    pn-PA
    se-like-62
    transcription unit II
    NP_476684.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2181211..2182916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057336.5 → NP_476684.1  prune [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18399, Q629J6
      Related
      FBpp0070373
      Conserved Domains (2) summary
      COG1227
      Location:39 → 379
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:235 → 377
      DHHA2; DHHA2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18399 O18399
    Q24465 Q24465
    Q629J6 Q629J6

    Gene LinkOut

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