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    kat-60L1 katanin p60-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kat-60L1provided by FlyBase
    Official Full Name
    katanin p60-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037375
    Locus tag
    Dmel_CG1193
    See related
    AllianceGenome:FB:FBgn0037375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1193; DmCG1193; Dmel\CG1193; Kat-60L1; kat60L1
    Summary
    Enables microtubule severing ATPase activity. Involved in microtubule severing; neuron remodeling; and positive regulation of dendrite morphogenesis. Located in ciliary basal body and microtubule. Is expressed in several structures, including embryonic antennal sense organ; embryonic central brain neurons; embryonic head sensory system; ganglia; and sensory cluster. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kat-60L1 in Genome Data Viewer
    Location:
    83C3-83C4; 3-47.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5781762..5787465)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1607484..1613187)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 8 Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene Histone acetyltransferase 1 Neighboring gene Regulatory particle non-ATPase 5 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). Baxter SL, et al. Dis Model Mech, 2014 Aug. PMID 24906373, Free PMC Article
    2. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. Stewart A, et al. J Neurosci, 2012 Aug 22. PMID 22915107, Free PMC Article
    3. Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. Tao J, et al. J Neurosci, 2011 Apr 6. PMID 21471375, Free PMC Article
    4. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Lee HH, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19329489, Free PMC Article
    5. Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. Zhang D, et al. J Cell Biol, 2007 Apr 23. PMID 17452528, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia.
      Title: Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia.
    2. The results of this study propose Kat-60L1 plays a unique role in regulating microtubules to promote terminal arborization and function of class IV sensory neuron dendrites
      Title: Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
    3. found a role for Katanin p60-like 1 (Kat-60L1) in facilitating dendrite severing by breaking microtubule in proximal dendrites, where the dendrites subsequently separate from the soma.
      Title: Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule severing ATPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    katanin p60-like 1
    Names
    CG1193-PA
    CG1193-PB
    CG1193-PC
    CG1193-PD
    CG1193-PE
    CG1193-PF
    CG1193-PG
    CG1193-PH
    Katanin-p60L1
    kat-60L1-PA
    kat-60L1-PB
    kat-60L1-PC
    kat-60L1-PD
    kat-60L1-PE
    kat-60L1-PF
    kat-60L1-PG
    kat-60L1-PH
    katanin
    NP_001163521.1
    NP_001163522.1
    NP_001163523.1
    NP_001163524.1
    NP_001163525.1
    NP_001163526.1
    NP_649586.1
    NP_731004.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5781762..5787465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170055.1 → NP_001163526.1  katanin p60-like 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163526.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ62
      Conserved Domains (3) summary
      smart00382
      Location:362 → 501
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:366 → 499
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:574 → 607
      Vps4_C; Vps4 C terminal oligomerization domain

    2. NM_141329.3 → NP_649586.1  katanin p60-like 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961H1
      Related
      FBpp0078276
      Conserved Domains (3) summary
      smart00382
      Location:358 → 497
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:362 → 495
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:570 → 603
      Vps4_C; Vps4 C terminal oligomerization domain

    3. NM_001170051.1 → NP_001163522.1  katanin p60-like 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163522.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ62
      Conserved Domains (3) summary
      smart00382
      Location:362 → 501
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:366 → 499
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:574 → 607
      Vps4_C; Vps4 C terminal oligomerization domain

    4. NM_001170053.1 → NP_001163524.1  katanin p60-like 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961H1
      Conserved Domains (3) summary
      smart00382
      Location:358 → 497
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:362 → 495
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:570 → 603
      Vps4_C; Vps4 C terminal oligomerization domain

    5. NM_001170054.1 → NP_001163525.1  katanin p60-like 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QPP5
      Conserved Domains (3) summary
      smart00382
      Location:426 → 565
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:430 → 563
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:638 → 671
      Vps4_C; Vps4 C terminal oligomerization domain

    6. NM_169105.2 → NP_731004.1  katanin p60-like 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731004.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNI0, Q9VNI1
      Related
      FBpp0078277
      Conserved Domains (3) summary
      smart00382
      Location:422 → 561
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:426 → 559
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:634 → 667
      Vps4_C; Vps4 C terminal oligomerization domain

    7. NM_001170052.1 → NP_001163523.1  katanin p60-like 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QPP5
      Conserved Domains (3) summary
      smart00382
      Location:426 → 565
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:430 → 563
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:638 → 671
      Vps4_C; Vps4 C terminal oligomerization domain

    8. NM_001170050.1 → NP_001163521.1  katanin p60-like 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNI0, Q9VNI1
      Conserved Domains (3) summary
      smart00382
      Location:422 → 561
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:426 → 559
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:634 → 667
      Vps4_C; Vps4 C terminal oligomerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJ62 E1JJ62
    Q4QPP5 Q4QPP5
    Q961H1 Q961H1
    Q9VNI0 Q9VNI0

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