Lkb1 Lkb1 kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lkb1provided by FlyBase
Official Full Name: Lkb1 kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0038167
Locus tag: Dmel_CG9374
See related: AllianceGenome:FB:FBgn0038167
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey135; CG9374; dlkb1; dLKB1; Dmel\CG9374; DmLKB1; lkb1; LKB1; LKB1/PEUTZ JEGHERS KINASE; par-4; PAR-4; Par4; PAR4; STK11
Summary: Enables protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; germ cell development; and regulation of intracellular signal transduction. Located in cell cortex; endosome; and nucleus. Is active in cytoplasmic side of plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87F7-87F9; 3-54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13676549..13679430)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9502271..9505152)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
Title: Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK.
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo.
Title: The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo.
Membrane-bound LKB1 is crucial for Drosophila development.
Title: Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.
define a CIII-PI3K-regulated endosomal signalling platform from which LKB1 directs epithelial polarity, the dysregulation of which endows LKB1 with tumour-promoting properties
Title: Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.
Data highlight a new dLKB1 function which seems to be required in the germline for the formation of the actin cone and suggest that dLKB1 posttranscriptional regulation in testis and involvement in spermatid morphogenesis are evolutionarily conserved features.
Title: Drosophila LKB1 is required for the assembly of the polarized actin structure that allows spermatid individualization.
Yorkie activity is controlled by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system
Title: Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.
Data suggest that that an Sgt1/Hsp90-LKB1-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
Title: Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.
LKB1-AMPK negatively regulated mTOR function in tumor.
Title: [Advances of LKB1-AMPK-mTOR Signaling Pathway in Tumor].
wdb- and lkb1-dependent lifespan extension is mediated by downregulation of S6K, a downstream component of the insulin/IGF and TOR signaling pathways.
Title: A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila.
These data suggest that in complex tissues, LKB1 acts on an array of targets to regulate cell polarity.
Title: LKB1 regulates polarity remodeling and adherens junction formation in the Drosophila eye.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell delamination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of neuroblast polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell cortex	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Lkb1 kinase

Names: CG9374-PA; CG9374-PB; CG9374-PC; CG9374-PD; CG9374-PE; CG9374-PF; CG9374-PH; CG9374-PI; CG9374-PJ; Lkb1-PA; Lkb1-PB; Lkb1-PC; Lkb1-PD; Lkb1-PE; Lkb1-PF; Lkb1-PH; Lkb1-PI; Lkb1-PJ; liver kinase B1; lkb1

NP_001163606.1

EC 2.7.11.1

NP_650302.1

EC 2.7.11.1

NP_731840.1

EC 2.7.11.1

NP_731841.1

EC 2.7.11.1

NP_731842.1

EC 2.7.11.1

NP_731843.1

EC 2.7.11.1

NP_731844.1

EC 2.7.11.1

NP_731845.1

EC 2.7.11.1

NP_731846.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13676549..13679430

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169544.2 → NP_731843.1 Lkb1 kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731843.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082280

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_001170135.2 → NP_001163606.1 Lkb1 kinase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163606.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169541.3 → NP_731840.1 Lkb1 kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731840.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082276

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169547.3 → NP_731846.1 Lkb1 kinase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731846.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082283

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169543.3 → NP_731842.1 Lkb1 kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731842.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082279

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169545.3 → NP_731844.1 Lkb1 kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731844.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082281

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_142045.4 → NP_650302.1 Lkb1 kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650302.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082277

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169546.3 → NP_731845.1 Lkb1 kinase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731845.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082282

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
NM_169542.3 → NP_731841.1 Lkb1 kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731841.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T9L5, Q9VFS7

Related

FBpp0082278

Conserved Domains (2) summary

smart00220
Location:172 → 435

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14119
Location:178 → 435

STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1