U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Taf3 TBP-associated factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43793, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Taf3provided by FlyBase
    Official Full Name
    TBP-associated factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0026262
    Locus tag
    Dmel_CG2009
    See related
    AllianceGenome:FB:FBgn0026262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bip-II; bip2; Bip2; BIP2; CG2009; dBIP2; Dmel\CG2009; dmTAF3; DmTAF3; dTAFII3; dTAF[[II]]155; i163; i31; TAF155; taf3; TAF3; TAFII155; TAF[[II]]155; TFIID
    Summary
    Enables several functions, including RNA polymerase II general transcription initiation factor binding activity; chromatin binding activity; and p53 binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in several structures, including embryonic/larval midgut; ganglia; larval nervous system; pole plasm; and primordial germ cell. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Taf3 in Genome Data Viewer
    Location:
    102C1-102C1; 4-0 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (459887..466828, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (480513..487454, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene legless Neighboring gene Calcium/calmodulin-dependent protein kinase I Neighboring gene antisense RNA:CR45126 Neighboring gene uncharacterized protein Neighboring gene asator Neighboring gene Zn finger homeodomain 2 Neighboring gene Thymine DNA glycosylase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Memory mechanisms of active transcription during cell division. Zhou GL, et al. Bioessays, 2005 Dec. PMID 16299763
    2. The BTB/POZ domain of the regulatory proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) interacts with the novel Drosophila TAF(II) factor BIP2/dTAF(II)155. Pointud JC, et al. Dev Biol, 2001 Sep 15. PMID 11543621
    3. Chigno/CG11180 and SUMO are Chinmo-interacting proteins with a role in Drosophila testes somatic support cells. Rinehart L, et al. PeerJ, 2024. PMID 38495765, Free PMC Article
    4. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. Bereczki O, et al. BMC Mol Biol, 2008 Jun 12. PMID 18549481, Free PMC Article
    5. Transcriptional activation by GAGA factor is through its direct interaction with dmTAF3. Chopra VS, et al. Dev Biol, 2008 May 15. PMID 18367161

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: c463013-462883 mobile_element_type = transposon:INE-1{}5931

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    TBP-associated factor 3
    Names
    Bric-a-brac interacting protein 2
    CG2009-PA
    TATA binding protein associated factor 3
    Taf3-PA
    bip2
    bric a brac interacting protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      459887..466828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143666.3 → NP_651923.2  TBP-associated factor 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651923.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1I0, Q9V4D4
      Related
      FBpp0088179
      Conserved Domains (2) summary
      smart00576
      Location:4 → 80
      BTP; Bromodomain transcription factors and PHD domain containing proteins
      cd15522
      Location:1342 → 1387
      PHD_TAF3; PHD finger found in transcription initiation factor TFIID subunit 3 (TAF3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSB9 Q8MSB9
    Q8T9I5 Q8T9I5
    Q95RM4 Q95RM4
    Q9U1I0 Q9U1I0
    Q9V4D4 Q9V4D4
    Q9XZU7 Q9XZU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous