l(2)gl lethal (2) giant larvae [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: l(2)glprovided by FlyBase
Official Full Name: lethal (2) giant larvaeprovided by FlyBase
Primary source: FLYBASE:FBgn0002121
Locus tag: Dmel_CG2671
See related: AllianceGenome:FB:FBgn0002121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2671; D-LGL; dlgl; Dmel\CG2671; gl; l(2); l(2) giant larva; l(2)giant larvae; L(2)gl; L(2)GL; l-gl; Lethal (2) giant larvae; lgl; Lgl; LGL; l[[2]]gl; MENE (2L)-B; p127; p127l(2)gl; p127[l(2)gl]; SN2-5
Summary: Enables several functions, including SNARE binding activity; myosin II binding activity; and protein kinase inhibitor activity. Involved in several processes, including cytoskeleton organization; generation of neurons; and regionalization. Located in several cellular components, including apicolateral plasma membrane; presynaptic membrane; and smooth septate junction. Is expressed in several structures, including ganglia; gut section; head; neuron projection bundle of larval ventral nerve cord; and somatic cell of ovariole. Used to study brain cancer; cancer; carcinoma; kidney cancer; and neuroblastoma. Orthologous to human LLGL1 (LLGL scribble cell polarity complex component 1) and LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21A2-21A4; 2-0 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9839..21376, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9839..21376, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway through a dual mechanism.
Title: The Drosophila tumour suppressor Lgl and Vap33 activate the Hippo pathway through a dual mechanism.
The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Title: The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila.
Title: Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila.
Hh signaling from de novo organizers drive lgl neoplasia in Drosophila epithelium.
Title: Hh signaling from de novo organizers drive lgl neoplasia in Drosophila epithelium.
Lgl cortical localization in epithelial cells depends on PP1-mediated dephosphorylation.
Title: PP1-Mediated Dephosphorylation of Lgl Controls Apical-basal Polarity.
Lgl promoted the activity of the V-ATPase by interacting with Vap33 (VAMP-associated protein of 33 kDa). Vap33 physically and genetically interacted with Lgl and V-ATPase subunits and repressed V-ATPase-mediated endosomal vesicle acidification and Notch signaling.
Title: Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex.
Here we show that PTEN mutation impacts aPKC and Lgl protein levels also in Drosophila. Moreover, we demonstrate that PI3K activation is not sufficient to trigger tumourigenesis, while aPKC promotes hyperplastic growth of the neuroepithelium and a noticeable expansion of the type II neuroblasts.
Title: Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila.
Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues, is reported.
Title: A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues.
results strongly suggest that the phenotypes we found in Sco mutants are more closely associated with the lgl allele than ectopic Snail activity
Title: Decreased expression of lethal giant larvae causes ovarian follicle cell outgrowth in the Drosophila Scutoid mutant.
Lgl plasma membrane (PB) domain contains all the identified phosphorylation sites of aPKC and Aurora kinases, providing a molecular mechanism by which phosphorylations neutralize the positive charges on the PB domain to inhibit Lgl PM targeting.
Title: A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c9949-9888 mobile_element_type = transposon:INE-1{}1749

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin II binding	IBA Inferred from Biological aspect of Ancestor more info
enables myosin II binding	IGI Inferred from Genetic Interaction more info	PubMed
enables myosin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	IGI Inferred from Genetic Interaction more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IPI Inferred from Physical Interaction more info	PubMed
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in basal protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of neuroblast polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of polarity of follicular epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in localization within membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septate junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in symmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in smooth septate junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lethal (2) giant larvae

Names: CG2671-PA; CG2671-PB; CG2671-PC; CG2671-PD; CG2671-PE; CG2671-PF; CG2671-PG; CG2671-PH; CG2671-PI; CG2671-PJ; CG2671-PK; Lgl; complementation group 2.1; l(2) giant larvae; l(2)gl-PA; l(2)gl-PB; l(2)gl-PC; l(2)gl-PD; l(2)gl-PE; l(2)gl-PF; l(2)gl-PG; l(2)gl-PH; l(2)gl-PI; l(2)gl-PJ; l(2)gl-PK; lethal (2) giant larva; lethal giant larva; lethal giant larvae; lethal giant larve; lethal(2) giant larvae; lethal(2)-giant larvae; lethal(2)giant larvae; lethal- giant-larvae; lethal-2-giant larvae; lethal-giant-larvae; suppressor of NA9 2-5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9839..21376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164352.3 → NP_722587.1 lethal (2) giant larvae, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722587.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08111

Related

FBpp0077827

Conserved Domains (1) summary

pfam08366
Location:219 → 289

LLGL; LLGL2
NM_001258873.2 → NP_001245802.1 lethal (2) giant larvae, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245802.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_001258872.2 → NP_001245801.1 lethal (2) giant larvae, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245801.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_164348.3 → NP_722583.1 lethal (2) giant larvae, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722583.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08111

Related

FBpp0077824

Conserved Domains (2) summary

pfam08366
Location:260 → 330

LLGL; LLGL2

sd00039
Location:31 → 70

7WD40; WD40 repeat [structural motif]
NM_164351.3 → NP_722586.1 lethal (2) giant larvae, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722586.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08111

Related

FBpp0077826

Conserved Domains (1) summary

pfam08366
Location:219 → 289

LLGL; LLGL2
NM_164350.3 → NP_722585.1 lethal (2) giant larvae, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722585.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08111

Related

FBpp0077825

Conserved Domains (1) summary

pfam08366
Location:219 → 289

LLGL; LLGL2
NM_001272858.1 → NP_001259787.1 lethal (2) giant larvae, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259787.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBJ2

Conserved Domains (3) summary

COG2319
Location:18 → 477

WD40; WD40 repeat [General function prediction only]

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_001258874.2 → NP_001245803.1 lethal (2) giant larvae, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245803.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_001258875.2 → NP_001245804.1 lethal (2) giant larvae, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245804.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_078715.4 → NP_523439.2 lethal (2) giant larvae, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523439.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Related

FBpp0077828

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]
NM_164349.3 → NP_722584.1 lethal (2) giant larvae, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_722584.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZW0, D0IQ91, D0IQJ0, P08111, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1

UniProtKB/TrEMBL

M9NCX1

Related

FBpp0077829

Conserved Domains (2) summary

pfam08366
Location:268 → 338

LLGL; LLGL2

sd00039
Location:39 → 78

7WD40; WD40 repeat [structural motif]