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    dsd distracted [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dsdprovided by FlyBase
    Official Full Name
    distractedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039528
    Locus tag
    Dmel_CG5634
    See related
    AllianceGenome:FB:FBgn0039528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5634; CT17798; Dmel\CG5634
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in synaptic target recognition. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in adult head. Orthologous to human ATRN (attractin) and ATRNL1 (attractin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dsd in Genome Data Viewer
    Location:
    98A10-98A10; 3-94 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27597563..27607396, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23423285..23433118, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene partner of inscuteable Neighboring gene uncharacterized protein Neighboring gene tusp Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1. Nawaratne V, et al. MicroPubl Biol, 2021. PMID 34235405, Free PMC Article
    2. Tubby domain superfamily protein is required for the formation of the 7S SNARE complex in Drosophila. Yoon EJ, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27888110
    3. Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues. Bányai L, et al. FEBS Lett, 2004 May 7. PMID 15135065
    4. Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Schroeder AM, et al. Hum Mol Genet, 2019 Dec 1. PMID 31625562, Free PMC Article
    5. Systematic identification of genes regulating synaptic remodeling in the Drosophila visual system. Araki T, et al. Genes Genet Syst, 2020 Aug 27. PMID 32493879

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    distracted
    Names
    CG5634-PB
    CG5634-PC
    attractin
    dsd-PB
    dsd-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27597563..27607396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276084.1 → NP_001263013.1  distracted, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R8, Q9VB20
      Conserved Domains (6) summary
      PLN02153
      Location:290 → 582
      PLN02153; epithiospecifier protein
      cd00041
      Location:86 → 212
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:948 → 994
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:482 → 531
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:821 → 870
      PSI; Plexin repeat
      pfam13854
      Location:355 → 391
      Kelch_5; Kelch motif

    2. NM_143314.4 → NP_651571.3  distracted, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651571.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R8, Q9VB20
      Conserved Domains (6) summary
      PLN02153
      Location:290 → 582
      PLN02153; epithiospecifier protein
      cd00041
      Location:86 → 212
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00055
      Location:948 → 994
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      sd00038
      Location:482 → 531
      Kelch; KELCH repeat [structural motif]
      pfam01437
      Location:821 → 870
      PSI; Plexin repeat
      pfam13854
      Location:355 → 391
      Kelch_5; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960R8 Q960R8
    Q9VB20 Q9VB20

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