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    ScpX Sterol carrier protein X-related thiolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ScpXprovided by FlyBase
    Official Full Name
    Sterol carrier protein X-related thiolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015808
    Locus tag
    Dmel_CG17320
    See related
    AllianceGenome:FB:FBgn0015808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17320; Dmel\CG17320
    Summary
    Predicted to enable acetyl-CoA C-acyltransferase activity; phospholipid transporter activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to be involved in phospholipid transport. Predicted to be active in peroxisome. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ScpX in Genome Data Viewer
    Location:
    37B1-37B1; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18831229..18833630)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18831229..18833630)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 36 member D1 Neighboring gene UDP-glycosyltransferase family 36 member E1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changes in Drosophila melanogaster midgut proteins in response to dietary Bowman-Birk inhibitor. Li HM, et al. Insect Mol Biol, 2007 Oct. PMID 17725801
    2. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Li HM, et al. Insect Mol Biol, 2010 Jun 1. PMID 20113373
    3. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Yin J, et al. Nat Commun, 2021 Apr 23. PMID 33893307, Free PMC Article
    4. Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model. Erkosar B, et al. FEBS Lett, 2014 Nov 17. PMID 24983497
    5. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyl-CoA C-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables propionyl-CoA C2-trimethyltridecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sterol carrier protein X-related thiolase
    Names
    CG17320-PA
    ScpX-PA
    sterol carrier protein x
    NP_524715.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18831229..18833630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079976.6 → NP_524715.2  sterol carrier protein X-related thiolase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524715.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24506, Q9VJ43
      Related
      FBpp0080659
      Conserved Domains (3) summary
      PRK08256
      Location:5 → 396
      PRK08256; lipid-transfer protein; Provisional
      cd00829
      Location:9 → 395
      SCP-x_thiolase; Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal ...
      pfam02036
      Location:429 → 529
      SCP2; SCP-2 sterol transfer family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24506 Q24506
    Q24507 Q24507
    Q9VJ43 Q9VJ43

    Gene LinkOut

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