aux auxilin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: auxprovided by FlyBase
Official Full Name: auxilinprovided by FlyBase
Primary source: FLYBASE:FBgn0037218
Locus tag: Dmel_CG1107
See related: AllianceGenome:FB:FBgn0037218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.393; Aux; AUX; Auxilin; auxillin; Auxillin/DNAJC6; CG1107; dAux; Dmel\CG1107; DNAJC6; GAK
Summary: Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in clathrin-dependent endocytosis; compound eye morphogenesis; and sperm individualization. Located in Golgi stack. Is expressed in several structures, including adult head; embryonic/larval garland cell; embryonic/larval midgut primordium; garland cell primordium; and salivary gland body primordium. Used to study Parkinson's disease and Parkinson's disease 19A. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to several human genes including GAK (cyclin G associated kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82A1-82A1; 3-47.1 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4211783..4227518)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (37505..53240)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila Rab11 and auxilin mutants to test the ligand recycling hypothesis.
Title: The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling.
Aux participates in forming these Golgi-derived clathrin-positive vesicles and therefore, has a role in the secretory pathway.
Title: Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis.
ligand endocytosis is critical for Notch signaling and auxilin participates in Notch signaling by facilitating ligand internalization
Title: The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis.
Auxilin, an endocytic factor that regulates Clathrin dynamics, is also essential for Notch signaling.
Title: Auxilin is essential for Delta signaling.
The data suggest that auxilin is an integral component of the Notch signaling pathway, participating in the ubiquitin-dependent endocytosis of Delta.
Title: Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 4215890-4215925 mobile_element_type = transposon:1360{}3728

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables AP-2 adaptor complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: auxilin

Names: CG1107-PA; CG1107-PB; CG1107-PC; CG1107-PD; aux-PA; aux-PB; aux-PC; aux-PD; auxillin

NP_001262243.1

EC 2.7.11.1

NP_001262244.1

EC 2.7.11.1

NP_649438.1

EC 2.7.11.1

NP_730785.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4211783..4227518

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164317.3 → NP_730785.1 auxilin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730785.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMY8

Related

FBpp0078604

Conserved Domains (4) summary

smart00271
Location:1110 → 1150

DnaJ; DnaJ molecular chaperone homology domain

smart00220
Location:51 → 317

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:581 → 711

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:49 → 326

PKc_like; Protein Kinases, catalytic domain
NM_141181.3 → NP_649438.1 auxilin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649438.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMY8

Related

FBpp0078605

Conserved Domains (4) summary

smart00271
Location:1110 → 1150

DnaJ; DnaJ molecular chaperone homology domain

smart00220
Location:51 → 317

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:581 → 711

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:49 → 326

PKc_like; Protein Kinases, catalytic domain
NM_001275314.1 → NP_001262243.1 auxilin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262243.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KG14

Conserved Domains (4) summary

smart00271
Location:1098 → 1138

DnaJ; DnaJ molecular chaperone homology domain

smart00220
Location:51 → 317

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:581 → 711

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:49 → 326

PKc_like; Protein Kinases, catalytic domain
NM_001275315.1 → NP_001262244.1 auxilin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262244.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KF57

Conserved Domains (5) summary

smart00271
Location:1102 → 1142

DnaJ; DnaJ molecular chaperone homology domain

smart00220
Location:58 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:573 → 703

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl10080
Location:927 → 1009

RPE65; Retinal pigment epithelial membrane protein

cl21453
Location:49 → 318

PKc_like; Protein Kinases, catalytic domain