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    Ublcp1 Ubiquitin-like domain-containing C-terminal domain phosphatase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ublcp1provided by FlyBase
    Official Full Name
    Ubiquitin-like domain-containing C-terminal domain phosphatase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027526
    Locus tag
    Dmel_CG6697
    See related
    AllianceGenome:FB:FBgn0027526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4972728; BcDNA:LD21504; CG6697; Dmel\CG6697; DmUBLCP1; UBLCP1
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of proteasome assembly. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human UBLCP1 (ubiquitin like domain containing CTD phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ublcp1 in Genome Data Viewer
    Location:
    94D10-94D10; 3-77 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23061493..23062751)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18887215..18888473)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46089 Neighboring gene p53 Neighboring gene Cystinosin Neighboring gene salvador Neighboring gene uncharacterized protein Neighboring gene Carrier of Wingless Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
    2. Identification and characterization of a Drosophila proteasome regulatory network. Lundgren J, et al. Mol Cell Biol, 2005 Jun. PMID 15899868, Free PMC Article
    3. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Sopko R, et al. Dev Cell, 2014 Oct 13. PMID 25284370, Free PMC Article
    4. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
    5. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like domain-containing C-terminal domain phosphatase 1
    Names
    CG6697-PA
    Ublcp1-PA
    NP_651118.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23061493..23062751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142861.4 → NP_651118.1  Ubiquitin-like domain-containing C-terminal domain phosphatase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XZ16
      Related
      FBpp0083740
      Conserved Domains (3) summary
      TIGR02245
      Location:120 → 314
      HAD_IIID1; HAD-superfamily subfamily IIID hydrolase, TIGR02245
      cd01813
      Location:12 → 79
      UBP_N; UBP ubiquitin processing protease
      smart00213
      Location:14 → 79
      UBQ; Ubiquitin homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ16.1 Q9XZ16

    Gene LinkOut

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