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    CG5033 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5033provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028744
    Locus tag
    Dmel_CG5033
    See related
    AllianceGenome:FB:FBgn0028744
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BOP1; Dmel\CG5033; dWDR36; EG:52C10.1
    Summary
    Predicted to enable ribonucleoprotein complex binding activity. Involved in regulation of hemocyte proliferation. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Is expressed in several structures, including embryonic/larval midgut primordium; head epidermis primordium; larval muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5033 in Genome Data Viewer
    Location:
    54E9-54E9; 2-84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17789679..17792448)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13677184..13679953)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-31a stem loop Neighboring gene adrift Neighboring gene Ubiquitin conjugating enzyme 10 Neighboring gene antisense RNA:CR45270 Neighboring gene Double hit Neighboring gene grainy head

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article
    2. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Hulf T, et al. Mol Cell Biol, 2005 May. PMID 15831447, Free PMC Article
    3. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Gerlach JM, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078288, Free PMC Article
    4. The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo. Schwinkendorf D, et al. Gene, 2009 May 1. PMID 19248823
    5. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Ebner A, et al. Gene, 2002 Apr 3. PMID 11992723

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of PeBoW complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5033-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17789679..17792448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137426.4 → NP_611270.1  uncharacterized protein Dmel_CG5033 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JQW4, Q7K0Y1
      Related
      FBpp0088519
      Conserved Domains (4) summary
      smart01035
      Location:171 → 436
      BOP1NT; BOP1NT (NUC169) domain
      COG2319
      Location:436 → 783
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:442 → 783
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:452 → 487
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0Y1.1 Q7K0Y1

    Gene LinkOut

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