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    pch2 pachytene checkpoint 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41013, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pch2provided by FlyBase
    Official Full Name
    pachytene checkpoint 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051453
    Locus tag
    Dmel_CG31453
    See related
    AllianceGenome:FB:FBgn0051453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11743; CG11744; CG31453; Dmel\CG31453; Pch2
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in meiotic recombination checkpoint signaling. Predicted to be active in chromosome and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pch2 in Genome Data Viewer
    Location:
    85A3-85A3; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8559540..8561764, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4385262..4387486, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45574 Neighboring gene Odorant receptor 85d Neighboring gene antisense RNA:CR44291 Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Interchromosomal Effect: Different Meanings for Different Organisms. Miller DE. Genetics, 2020 Nov. PMID 33158985, Free PMC Article
    2. Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice. Miao C, et al. Plant Cell, 2013 Aug. PMID 23943860, Free PMC Article
    3. Budding yeast Pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination. Farmer S, et al. PLoS One, 2012. PMID 22745819, Free PMC Article
    4. Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila. Pek JW, et al. Development, 2012 Dec. PMID 23136393
    5. Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis. Joyce EF, et al. PLoS Genet, 2010 Aug 12. PMID 20711363, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study propose a model in which Pch2 ensures efficient formation of meiotic DSBs which is necessary for igniting the subsequent meiotic checkpoint responses that lead to proper differentiation of meiotic recombinants.
      Title: Budding yeast Pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination.
    2. Delays in meiotic progression are suppressed by a mutation in the Drosophila homolog of pch2.
      Title: Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic recombination checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic recombination checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pachytene checkpoint 2
    Names
    CG31453-PA
    CG31453-PB
    pch2-PA
    pch2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8559540..8561764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300306.1 → NP_001287235.1  pachytene checkpoint 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX76
      Conserved Domains (2) summary
      smart00382
      Location:166 → 315
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:169 → 314
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_079558.5 → NP_524282.4  pachytene checkpoint 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524282.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX76
      Related
      FBpp0081381
      Conserved Domains (2) summary
      smart00382
      Location:166 → 315
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:169 → 314
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX76 Q8SX76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
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