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    Cyp6a13 Cytochrome P450 6a13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6a13provided by FlyBase
    Official Full Name
    Cytochrome P450 6a13provided by FlyBase
    Primary source
    FLYBASE:FBgn0033304
    Locus tag
    Dmel_CG2397
    See related
    AllianceGenome:FB:FBgn0033304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6a13; CG2397; cyp6a13; Cyp6A13; CYP6A13; Dmel\CG2397
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in defense response to bacterium. Is expressed in several structures, including adult head; embryonic head sensory system; embryonic labial sensory complex; embryonic/larval midgut; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6a13 in Genome Data Viewer
    Location:
    44D3-44D3; 2-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8570499..8572147)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4458004..4459652)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 6a14 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imidacloprid is hydroxylated by Laodelphax striatellus CYP6AY3v2. Wang R, et al. Insect Mol Biol, 2017 Oct. PMID 28654199
    2. Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. Norry FM, et al. J Insect Physiol, 2009 Nov. PMID 19651134
    3. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article
    4. Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Chen J, et al. Proc Natl Acad Sci U S A, 2010 Nov 30. PMID 21076039, Free PMC Article
    5. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 6a13
    Names
    CG2397-PA
    Cyp6a13-PA
    cytochrome P450
    NP_610390.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8570499..8572147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136546.3 → NP_610390.1  cytochrome P450 6a13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610390.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V4U9
      Related
      FBpp0087770
      Conserved Domains (1) summary
      pfam00067
      Location:33 → 476
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4U9.1 Q9V4U9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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