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    Magi magi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37403, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magiprovided by FlyBase
    Official Full Name
    magiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034590
    Locus tag
    Dmel_CG30388
    See related
    AllianceGenome:FB:FBgn0034590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15656; CG30388; CG4117; D-MAGI; Dmel\CG30388; ima; Ima; magi
    Summary
    Enables small GTPase binding activity. Involved in adherens junction organization. Located in several cellular components, including adherens junction; apicolateral plasma membrane; and muscle cell postsynaptic specialization. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to several human genes including MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Magi in Genome Data Viewer
    Location:
    57C2-57C3; 2-93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21129463..21142261, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17016968..17029766, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene king tubby Neighboring gene uncharacterized protein Neighboring gene Transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene mago nashi Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity. Maywald ML, et al. Front Cell Dev Biol, 2022. PMID 35372328, Free PMC Article
    2. Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6. Padash Barmchi M, et al. Sci Rep, 2021 Jan 13. PMID 33441820, Free PMC Article
    3. Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization. Packard M, et al. Neuron, 2015 May 20. PMID 25959729, Free PMC Article
    4. Identification and expression of Ima, a novel Ral-interacting Drosophila protein. Beller M, et al. Mech Dev, 2002 Dec. PMID 14516694
    5. Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex. Padash Barmchi M, et al. PLoS One, 2016. PMID 27074039, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of Magi resulted in the displacement of Baz/Par3 and aPKC and lead to an increase in the level of PIP3. we found that Magi and Baz functioned in an antagonistic manner to regulate the localization of the apical polarity complex.
      Title: Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex.
    2. Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye.
      Title: Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    magi
    Names
    CG30388-PA
    CG30388-PB
    CG30388-PC
    Magi-PA
    Magi-PB
    Magi-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21129463..21142261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137707.3 → NP_611551.1  magi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T15, Q9W2L2
      Related
      FBpp0071559
      Conserved Domains (5) summary
      smart00228
      Location:925 → 1011
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:455 → 534
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00201
      Location:342 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:1029 → 1110
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:294 → 323
      WW; WW domain

    2. NM_001299732.1 → NP_001286661.1  magi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T15, Q9W2L2
      Conserved Domains (5) summary
      smart00228
      Location:925 → 1011
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:455 → 534
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00201
      Location:342 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:1029 → 1110
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:294 → 323
      WW; WW domain

    3. NM_001299733.1 → NP_001286662.1  magi, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T15, Q9W2L2
      Conserved Domains (5) summary
      smart00228
      Location:925 → 1011
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:455 → 534
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00201
      Location:342 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:1029 → 1110
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:294 → 323
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX30 Q8SX30
    Q9W2L2 Q9W2L2

    Gene LinkOut

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