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    Hpf1 Histone PARylation factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hpf1provided by FlyBase
    Official Full Name
    Histone PARylation factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037377
    Locus tag
    Dmel_CG1218
    See related
    AllianceGenome:FB:FBgn0037377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1218; dHpf1; Dmel\CG1218
    Summary
    Enables poly-ADP-D-ribose binding activity and zinc ion binding activity. Involved in DNA damage response. Is active in site of DNA damage. Is expressed in several structures, including antennal primordium; anterior endoderm; ganglia; head epidermis primordium; and mesoderm. Orthologous to human HPF1 (histone PARylation factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hpf1 in Genome Data Viewer
    Location:
    83C4-83C4; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5791879..5793383)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1617601..1619105)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Regulatory particle non-ATPase 5 Neighboring gene Proteasome assembly chaperone 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of a zinc-finger domain that binds to poly-ADP-ribose. Isogai S, et al. Genes Cells, 2010 Feb. PMID 20088964
    2. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Valakh V, et al. Dev Biol, 2012 Jun 15. PMID 22542760, Free PMC Article
    3. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
    4. HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity. Gibbs-Seymour I, et al. Mol Cell, 2016 May 5. PMID 27067600, Free PMC Article
    5. Integrating computational biology and forward genetics in Drosophila. Aerts S, et al. PLoS Genet, 2009 Jan. PMID 19165344, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly-ADP-D-ribose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly-ADP-D-ribose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of DNA damage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone PARylation factor 1
    Names
    CG1218-PA
    Hpf1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5791879..5793383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141332.4 → NP_649589.1  histone PARylation factor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T050, Q9VNI3
      Related
      FBpp0078279
      Conserved Domains (2) summary
      pfam10228
      Location:178 → 428
      DUF2228; uncharacterized conserved protein (DUF2228)
      pfam10283
      Location:4 → 25
      zf-CCHH; Zinc-finger (CX5CX6HX5H) motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNI3.2 Q9VNI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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