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    uri unconventional prefoldin RPB5 interactor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uriprovided by FlyBase
    Official Full Name
    unconventional prefoldin RPB5 interactorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035025
    Locus tag
    Dmel_CG11416
    See related
    AllianceGenome:FB:FBgn0035025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11416; Dmel\CG11416; dURI; ori
    Summary
    Enables phosphatase inhibitor activity. Involved in spermatogenesis. Located in cytoplasm and polytene chromosome. Is expressed in several structures, including imaginal disc; larval brain; male germline cell; salivary gland; and testis. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See uri in Genome Data Viewer
    Location:
    60D5-60D5; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24565554..24568082)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20453077..20455605)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleosome remodeling factor - 38kD Neighboring gene uncharacterized protein Neighboring gene TFIIF-interacting CTD phosphatase Neighboring gene uncharacterized protein Neighboring gene Start1 Neighboring gene SIFamide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. Kirchner J, et al. BMC Mol Biol, 2008 Apr 15. PMID 18412953, Free PMC Article
    2. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    3. Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis. White-Cooper H. Spermatogenesis, 2012 Jan 1. PMID 22553486, Free PMC Article
    4. Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation. Tiwari MD, et al. Biol Open, 2019 Nov 12. PMID 31649115, Free PMC Article
    5. The Drosophila melanogaster sperm proteome-II (DmSP-II). Wasbrough ER, et al. J Proteomics, 2010 Oct 10. PMID 20833280

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unconventional prefoldin RPB5 interactor
    Names
    CG11416-PA
    origami
    uri-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24565554..24568082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138089.4 → NP_611933.1  unconventional prefoldin RPB5 interactor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611933.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T044, Q9W148
      Related
      FBpp0072215
      Conserved Domains (1) summary
      pfam02996
      Location:8 → 124
      Prefoldin; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W148.1 Q9W148

    Gene LinkOut

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