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    Liprin-alpha Liprin-alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 249072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Liprin-alphaprovided by FlyBase
    Official Full Name
    Liprin-alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0046704
    Locus tag
    Dmel_CG11199
    See related
    AllianceGenome:FB:FBgn0046704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11199; DLiprin; Dliprin-alpha; DLiprin-alpha; Dmel\CG11199; LIP; lip-alpha; LIP.1; LIP1; liprin; Liprin; liprin-alpha; lpr; LPR; oos
    Summary
    Involved in several processes, including anterograde synaptic vesicle transport; neuron development; and synapse organization. Located in focal adhesion and presynaptic active zone. Part of protein-containing complex. Is active in neuromuscular junction and presynaptic cytosol. Is expressed in several structures, including adult head; ganglia; larval central nervous system; presumptive embryonic/larval system; and spermatozoon. Orthologous to several human genes including PPFIA1 (PTPRF interacting protein alpha 1) and PPFIA2 (PTPRF interacting protein alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Liprin-alpha in Genome Data Viewer
    Location:
    27A1-27A2; 2-22 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6723903..6732766)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6723903..6732766)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Apoptosis antagonizing transcription factor Neighboring gene homer Neighboring gene Tubulin tyrosine ligase-like 3B Neighboring gene Tubulin tyrosine ligase-like 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3. Paul MS, et al. Am J Hum Genet, 2024 Jan 4. PMID 38181735, Free PMC Article
    2. Getting a GRIP on liprins. Baran R, et al. Neuron, 2002 Mar 28. PMID 11931733
    3. Structural and functional plasticity of the cytoplasmic active zone. Sigrist SJ, et al. Curr Opin Neurobiol, 2011 Feb. PMID 20832284
    4. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Hofmeyer K, et al. Proc Natl Acad Sci U S A, 2006 Aug 1. PMID 16864797, Free PMC Article
    5. Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents. Yonekura S, et al. Dev Biol, 2007 Apr 15. PMID 17320070, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our live data support a "serial synapse formation" model, where at any time point only 1-2 "synaptogenic" filopodia suppress the synaptic competence of other filopodia through competition for synaptic seeding factors. Loss of the synaptic seeding factors Syd-1 and Liprin-alpha leads to a loss of this suppression, filopodial destabilization, and reduced synapse formation.
      Title: Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.
    2. Loss of function of liprin-alpha causes accumulation of ectopic materials in synapses of distal axons.
      Title: Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
    3. Context-specific interactions among three liprins (liprin-alpha, -beta, and -gamma) suggest that the R7 photoreceptor and neuromuscular junction synapses differ in their assembly mechanisms.
      Title: Three Drosophila liprins interact to control synapse formation.
    4. Data demonstrate that N-cadherin, DLAR, and Liprin-alpha function in a complex to regulate adhesive interactions between pre- and post-synaptic cells and provide a novel mechanism for controlling the activity of Liprin-alpha in the developing growth cone.
      Title: Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.
    5. Results suggest that Liprin-alpha does not simply act by regulating receptor tyrosine phosphatase LAR localization but also has LAR-independent functions.
      Title: Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R7 cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic active zone organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinal ganglion cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Liprin-alpha
    Names
    CG11199-PA
    CG11199-PB
    CG11199-PC
    CG11199-PD
    CG11199-PE
    LAR-interacting protein 1
    Liprin-a
    Liprin-alpha-PA
    Liprin-alpha-PB
    Liprin-alpha-PC
    Liprin-alpha-PD
    Liprin-alpha-PE
    dliprin
    dliprin-alpha
    liprin
    liprin-alpha
    out of step

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6723903..6732766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273224.1 → NP_001260153.1  Liprin-alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC73
      Conserved Domains (7) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:986 → 1051
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1071 → 1142
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:899 → 965
      SAM; Sterile alpha motif
      COG1340
      Location:35 → 376
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam14739
      Location:251 → 356
      DUF4472; Domain of unknown function (DUF4472)
      cl17182
      Location:26 → 106
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    2. NM_164707.3 → NP_723208.1  Liprin-alpha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM93
      Related
      FBpp0078931
      Conserved Domains (8) summary
      cd09562
      Location:942 → 1012
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1029 → 1094
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1114 → 1185
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:942 → 1008
      SAM; Sterile alpha motif
      COG1340
      Location:35 → 391
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam09728
      Location:250 → 522
      Taxilin; Myosin-like coiled-coil protein
      pfam15233
      Location:279 → 404
      SYCE1; Synaptonemal complex central element protein 1
      cl17182
      Location:26 → 106
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    3. NM_001273225.1 → NP_001260154.1  Liprin-alpha, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCR7
      Conserved Domains (9) summary
      cd09562
      Location:946 → 1016
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1033 → 1098
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1118 → 1189
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:946 → 1012
      SAM; Sterile alpha motif
      COG1340
      Location:35 → 391
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam09728
      Location:250 → 526
      Taxilin; Myosin-like coiled-coil protein
      pfam15233
      Location:279 → 404
      SYCE1; Synaptonemal complex central element protein 1
      cl12013
      Location:340 → 491
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17182
      Location:26 → 106
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    4. NM_135223.3 → NP_609067.2  Liprin-alpha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609067.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM93
      Related
      FBpp0078930
      Conserved Domains (8) summary
      cd09562
      Location:942 → 1012
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1029 → 1094
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1114 → 1185
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:942 → 1008
      SAM; Sterile alpha motif
      COG1340
      Location:35 → 391
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam09728
      Location:250 → 522
      Taxilin; Myosin-like coiled-coil protein
      pfam15233
      Location:279 → 404
      SYCE1; Synaptonemal complex central element protein 1
      cl17182
      Location:26 → 106
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

    5. NM_001273226.1 → NP_001260155.1  Liprin-alpha, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCD4
      Conserved Domains (8) summary
      cd09562
      Location:942 → 1012
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1029 → 1094
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1114 → 1185
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:942 → 1008
      SAM; Sterile alpha motif
      COG1340
      Location:35 → 391
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam09728
      Location:250 → 522
      Taxilin; Myosin-like coiled-coil protein
      pfam15233
      Location:279 → 404
      SYCE1; Synaptonemal complex central element protein 1
      cl17182
      Location:26 → 106
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC73 M9PC73
    M9PCD4 M9PCD4
    M9PCR7 M9PCR7
    Q9VM93 Q9VM93

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