Pli Pellino [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pliprovided by FlyBase
Official Full Name: Pellinoprovided by FlyBase
Primary source: FLYBASE:FBgn0025574
Locus tag: Dmel_CG5212
See related: AllianceGenome:FB:FBgn0025574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5212; Dmel\CG5212; PAP; pellino; PELLINO; pli
Summary: Enables kinase regulator activity and ubiquitin-protein transferase activity. Involved in several processes, including protein K48-linked ubiquitination; regulation of Toll signaling pathway; and regulation of defense response. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in adult fat body and organism. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including PELI2 (pellino E3 ubiquitin protein ligase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23860162..23890052, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19685884..19715774, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antifungal innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Toll signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K48-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of Toll signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed