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    pigeon pigeon [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pigeonprovided by FlyBase
    Official Full Name
    pigeonprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010309
    Locus tag
    Dmel_CG10739
    See related
    AllianceGenome:FB:FBgn0010309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10739; Dmel\CG10739; lio; pio
    Summary
    Predicted to be involved in positive regulation of amyloid-beta formation. Predicted to be active in trans-Golgi network. Is expressed in organism. Orthologous to human GSAP (gamma-secretase activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pigeon in Genome Data Viewer
    Location:
    37C7-37C7; 2-54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19186043..19189938)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19186043..19189938)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene gamma-Tubulin at 37C Neighboring gene uncharacterized protein Neighboring gene derailed Neighboring gene long non-coding RNA:CR46209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of linotte causes behavioral defects independently of pigeon in Drosophila. Moreau-Fauvarque C, et al. Neuroreport, 2002 Dec 3. PMID 12488817
    2. Protein kinases: which one is the memory molecule? Micheau J, et al. Cell Mol Life Sci, 1999 Apr. PMID 10357224, Free PMC Article
    3. The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product. Dura JM, et al. FEBS Lett, 1995 Aug 21. PMID 7656987
    4. The receptor tyrosine kinase gene linotte is required for neuronal pathway selection in the Drosophila mushroom bodies. Moreau-Fauvarque C, et al. Mech Dev, 1998 Nov. PMID 9858681
    5. Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster. Dura JM, et al. J Neurogenet, 1993 Aug. PMID 8295074

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of amyloid-beta formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pigeon
    Names
    CG10739-PA
    CG10739-PB
    linotte
    lionette
    pigeon-PA
    pigeon-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19186043..19189938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201915.2 → NP_001188844.1  pigeon, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRW6
      Conserved Domains (1) summary
      pfam14959
      Location:694 → 807
      GSAP-16; gamma-Secretase-activating protein C-term

    2. NM_057598.5 → NP_476946.1  pigeon, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24118, Q9VIY7
      Related
      FBpp0080735
      Conserved Domains (1) summary
      pfam14959
      Location:694 → 807
      GSAP-16; gamma-Secretase-activating protein C-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRW6 M9MRW6
    Q24118.2 Q24118

    Gene LinkOut

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