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    GluProRS Glutamyl-prolyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GluProRSprovided by FlyBase
    Official Full Name
    Glutamyl-prolyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005674
    Locus tag
    Dmel_CG5394
    See related
    AllianceGenome:FB:FBgn0005674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aa-tRNA-syn-glupro; AATS; Aats-glu; Aats-glupro; AATs-GluPro; CG5394; Dmel\CG5394; EPRS; ERS; FBpp0083898; Glu-ProRS; GluPro-RS; GluRS; glutamyl-prolyl-tRNA synthetase; p200
    Summary
    Enables glutamate-tRNA ligase activity and proline-tRNA ligase activity. Involved in glutamyl-tRNA aminoacylation and prolyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluProRS in Genome Data Viewer
    Location:
    95D1-95D1; 3-82 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23952136..23958391, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19777858..19784113, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutamate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46092 Neighboring gene Adaptor Protein complex 1, sigma subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DoMosaics: software for domain arrangement visualization and domain-centric analysis of proteins. Moore AD, et al. Bioinformatics, 2014 Jan 15. PMID 24222210
    2. A gene fusion event in the evolution of aminoacyl-tRNA synthetases. Berthonneau E, et al. FEBS Lett, 2000 Mar 31. PMID 10745085
    3. Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex. Cerini C, et al. Eur J Biochem, 1997 Feb 15. PMID 9063462
    4. A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase. Cerini C, et al. EMBO J, 1991 Dec. PMID 1756734, Free PMC Article
    5. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in prolyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prolyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in prolyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prolyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutamyl-prolyl-tRNA synthetase
    Names
    CG5394-PA
    CG5394-PB
    GluProRS-PA
    GluProRS-PB
    Glutamyl-tRNA synthetase
    aminoacyl-tRNA synthetase
    bifunctional aminoacyl-tRNA synthetase
    glutamyl-prolyl-tRA synthetase
    transfer RNA-Glu-Pro aminoacyl synthetase
    NP_524471.2
    NP_732925.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23952136..23958391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079747.3 → NP_524471.2  Glutamyl-prolyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524471.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28668, Q8IGR4, Q8IMX9, Q95TL3, Q9VCF5
      Related
      FBpp0083898
      Conserved Domains (9) summary
      cd10309
      Location:76 → 153
      GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
      PLN02907
      Location:1 → 715
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:1220 → 1714
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:1224 → 1486
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:1492 → 1714
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      cd00936
      Location:973 → 1022
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:748 → 799
      WHEP-TRS; WHEP-TRS domain
      pfam00749
      Location:203 → 508
      tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
      pfam03950
      Location:510 → 688
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

    2. NM_170103.2 → NP_732925.1  Glutamyl-prolyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732925.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8F4R5
      Related
      FBpp0083899
      Conserved Domains (5) summary
      PRK08661
      Location:502 → 996
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:506 → 768
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:774 → 996
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      cd00936
      Location:30 → 79
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:176 → 227
      WHEP-TRS; WHEP-TRS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28668.2 P28668

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